Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	24855
Country	Ethiopia

Received	2016-02-12 10:41
Peer-Review Started	2016-02-12 19:21
To Make the First Decision	2016-03-23 17:33
Return for Revision	2016-03-24 09:29
Revised	2016-04-15 15:13
Second Decision	2016-06-01 17:25
Accepted by Journal Editor-in-Chief	2016-06-01 23:23
Accepted by Executive Editor-in-Chief	2016-06-16 11:57
Articles in Press	2016-06-16 11:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-26 15:12
Publish the Manuscript Online	2016-08-09 08:50

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Apoptotic pathways as a therapeutic target for colorectal cancer treatment
Manuscript Source	Unsolicited Manuscript
All Author List	Aman M Abraha and Ezra B Ketema
Funding Agency and Grant Number
Corresponding Author	Ezra B Ketema, MSc, Department of Medical Biochemistry, College of Health Sciences, Mekelle University, Mekelle 1871, Ethiopia. aga.bely@gmail.com
Key Words	Colorectal cancer; Apoptotic pathways; Drug resistance; Colorectal cancer therapies; Apoptosis
Core Tip	Evasion of apoptosis has been established as a prominent hallmark of several human cancers, contributing to both tumor progression and chemo-resistance. In colorectal cancer development, the balance between the rates of cell growth and apoptosis that maintains intestinal epithelial cell homeostasis is impaired progressively. Recent studies indicated that failure of apoptosis may be an important factor in the evolution of colorectal cancer and its poor response to chemotherapy and radiation. We herein discussed the mechanisms of apoptosis, abnormal expression of apoptosis-related genes and future promises of apoptotic pathways as a therapeutic target for colorectal cancer chemoprevention and treatment.
Publish Date	2016-08-09 08:50
Citation	Abraha AM, Ketema EB. Apoptotic pathways as a therapeutic target for colorectal cancer treatment. World J Gastrointest Oncol 2016; 8(8): 583-591
URL	http://www.wjgnet.com/1948-5204/full/v8/i8/583.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i8.583

Full Article (PDF)	WJGO-8-583.pdf
Full Article (Word)	WJGO-8-583.doc
Manuscript File	24855-Review.docx
Answering Reviewers	24855-Answering reivewers.pdf
Audio Core Tip	24855-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	24855-Conflict-of-interest statement.pdf
Copyright License Agreement	24855-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	24855-Language certificate.pdf
Peer-review Report	24855-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24855-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24855-Scientific misconduct check.pdf
Scientific Editor Work List	24855-Scientific editor work list.pdf