Publication Name	World Journal of Gastroenterology
Manuscript ID	24863
Country	Japan

Received	2016-02-16 14:42
Peer-Review Started	2016-02-23 10:14
To Make the First Decision	2016-03-21 09:20
Return for Revision	2016-03-21 13:54
Revised
Second Decision	2016-05-05 16:45
Accepted by Journal Editor-in-Chief	2016-05-07 01:48
Accepted by Executive Editor-in-Chief	2016-05-23 16:48
Articles in Press	2016-05-23 16:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-06 15:02
Publish the Manuscript Online	2016-07-06 16:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis
Manuscript Source	Invited Manuscript
All Author List	Kazuhiro Shimazu, Koji Fukuda, Taichi Yoshida, Masahiro Inoue and Hiroyuki Shibata
Funding Agency and Grant Number
Corresponding Author	Hiroyuki Shibata, Professor, Department of Clinical Oncology, Graduate School of Medicine, Akita University, 3 Akita Prefecture, Akita Akita 010-8543, Japan. hiroyuki@med.akita-u.ac.jp
Key Words	Bone metastasis; Circulating tumor cell; Gastric cancer; Predictive biomarker; Prognostic biomarker
Core Tip	It has been reported in many times that a specific subtype of gastric cancer characterized with diffuse bone metastases at diagnosis, rapid progression and poorer prognosis apparently exists in almost one of ten gastric cancers. However, the basic and biological features of this subtype are not specified until today. In this study, we identified high number of circulating tumor cell of this subtype, and considered that circulating tumor cells (CTC) is responsible for the clinical features described above. CTC is not only a biological hallmark of this subtype, but also informative as a predictive or prognostic biomarkers.
Publish Date	2016-07-06 16:53
Citation	Shimazu K, Fukuda K, Yoshida T, Inoue M, Shibata H. High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis. World J Gastroenterol 2016; 22(26): 6083-6088
URL	http://www.wjgnet.com/1007-9327/full/v22/i26/6083.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i26.6083

Full Article (PDF)	WJG-22-6083.pdf
Full Article (Word)	WJG-22-6083.doc
Manuscript File	24863-Review.docx
Answering Reviewers	24863-Answering reviewers.pdf
Audio Core Tip	24863-Audio core tip.mp3
Biostatistics Review Certificate	24863-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	24863-Conflict-of-interest statement.pdf
Copyright License Agreement	24863-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	24863-Institutional review board statement.pdf
Peer-review Report	24863-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24863-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24863-Scientific misconduct check.pdf
Scientific Editor Work List	24863-Scientific editor work list.pdf