| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Marina Chianello Nicolau, Luis Felipe Ribeiro Pinto, Pedro Nicolau-Neto, Paulo Roberto Alves de Pinho, Ana Rossini, Tatiana de Almeida Simão and Sheila Coelho Soares Lima |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Ministério da Saúde (INCA) and Swiss Bridge Foundation |
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| Corresponding Author |
Sheila Coelho Soares Lima, PhD, Researcher, Programa de Carcinogênese Molecular, Instituto Nacional de Câncer, Coordenação de Pesquisa, Rua André Cavalcanti, 37 - 6º andar, Bairro de Fátima, Rio de Janeiro 20231-050, Brazil. sheilacoelho@gmail.com |
| Key Words |
Nicotinic cholinergic receptors; Esophagus; Esophageal squamous cell carcinoma; Tobacco; Alcohol; Gene expression |
| Core Tip |
Esophageal squamous cell carcinoma (ESCC) is the main histological subtype of esophageal cancer, and is associated with alcohol and tobacco consumption. Tobacco components, such as nicotine and nitrosamines, are high-affinity agonists of nicotinic cholinergic receptors (CHRNs), the activation of which triggers cellular signaling pathways important for cancer progression. However, data regarding differential expression and regulation of CHRNs in healthy esophageal mucosa and ESCC are limited. This study shows homogeneous expression of CHRNs along healthy esophagus and deregulation in ESCC, CHRNB4 overexpression preceding the first histopathological alterations during ESCC development, and CHRNA5 expression as an independent predictor of prognosis.
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| Publish Date |
2016-08-15 10:30 |
| Citation |
Chianello Nicolau M, Pinto LFR, Nicolau-Neto P, de Pinho PRA, Rossini A, de Almeida Simão T, Soares Lima SC. Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value. World J Gastroenterol 2016; 22(31): 7146-7156 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i31/7146.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i31.7146 |
