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8/15/2016 10:30:00 AM | Browse: 446 | Download: 577
Publication Name World Journal of Gastroenterology
Manuscript ID 24870
Country/Territory Brazil
2016-02-12 09:56
Peer-Review Started
2016-02-12 19:09
To Make the First Decision
2016-03-21 09:19
Return for Revision
2016-03-21 13:54
2016-04-15 04:20
Second Decision
2016-04-26 12:06
Accepted by Journal Editor-in-Chief
2016-04-28 17:31
Accepted by Company Editor-in-Chief
2016-05-04 16:48
Articles in Press
2016-05-04 16:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-08-05 16:55
Publish the Manuscript Online
2016-08-15 10:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Cohort Study
Article Title Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value
Manuscript Source Unsolicited Manuscript
All Author List Marina Chianello Nicolau, Luis Felipe Ribeiro Pinto, Pedro Nicolau-Neto, Paulo Roberto Alves de Pinho, Ana Rossini, Tatiana de Almeida Simão and Sheila Coelho Soares Lima
Funding Agency and Grant Number
Funding Agency Grant Number
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Ministério da Saúde (INCA) and Swiss Bridge Foundation
Corresponding author Sheila Coelho Soares Lima, PhD, Researcher, Programa de Carcinogênese Molecular, Instituto Nacional de Câncer, Coordenação de Pesquisa, Rua André Cavalcanti, 37 - 6º andar, Bairro de Fátima, Rio de Janeiro 20231-050, Brazil. sheilacoelho@gmail.com
Keywords Nicotinic cholinergic receptors; Esophagus; Esophageal squamous cell carcinoma; Tobacco; Alcohol; Gene expression
Core Tip Esophageal squamous cell carcinoma (ESCC) is the main histological subtype of esophageal cancer, and is associated with alcohol and tobacco consumption. Tobacco components, such as nicotine and nitrosamines, are high-affinity agonists of nicotinic cholinergic receptors (CHRNs), the activation of which triggers cellular signaling pathways important for cancer progression. However, data regarding differential expression and regulation of CHRNs in healthy esophageal mucosa and ESCC are limited. This study shows homogeneous expression of CHRNs along healthy esophagus and deregulation in ESCC, CHRNB4 overexpression preceding the first histopathological alterations during ESCC development, and CHRNA5 expression as an independent predictor of prognosis.
Publish Date 2016-08-15 10:30
Citation Chianello Nicolau M, Pinto LFR, Nicolau-Neto P, de Pinho PRA, Rossini A, de Almeida Simão T, Soares Lima SC. Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value. World J Gastroenterol 2016; 22(31): 7146-7156
Url http://www.wjgnet.com/1007-9327/full/v22/i31/7146.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i31.7146
Full Article (PDF) WJG-22-7146.pdf
Full Article (Word) WJG-22-7146.doc
Manuscript File 24870-Review.docx
Answering Reviewers 24870-Answering reviewers.pdf
Audio Core Tip 24870-Audio core tip.mp3
Biostatistics Review Certificate 24870-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 24870-Conflict-of-interest statement.pdf
Copyright License Agreement 24870-Copyright assignment.pdf
Data Sharing Statement 24870-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 24870-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160212030723.pdf
Institutional Review Board Approval Form or Document 24870-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 24870-Language certificate.pdf
Peer-review Report 24870-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 24870-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 24870-Scientific misconduct check.pdf
Scientific Editor Work List 24870-Scientific editor work list.pdf