Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	24924
Country	Brazil

Received	2016-02-15 09:07
Peer-Review Started	2016-02-15 12:11
To Make the First Decision	2016-03-30 11:47
Return for Revision	2016-03-31 09:36
Revised	2016-04-14 02:15
Second Decision	2016-04-19 18:04
Accepted by Journal Editor-in-Chief	2016-04-19 23:28
Accepted by Executive Editor-in-Chief	2016-05-09 16:44
Articles in Press	2016-05-09 16:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-20 09:01
Publish the Manuscript Online	2016-08-01 11:49

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Intestinal neuronal dysplasia type B: A still little known diagnosis for organic causes of intestinal chronic constipation
Manuscript Source	Invited Manuscript
All Author List	Pedro Luiz Toledo de Arruda Lourenção, Simone Antunes Terra, Erika Veruska Paiva Ortolan and Maria Aparecida Marchesan Rodrigues
Funding Agency and Grant Number	Funding Agency Grant Number São Paulo Research Foundation (FAPESP) 2014/042271-1
Corresponding Author	Pedro Luiz Toledo de Arruda Lourenção, Professor of Pediatric Surgery, Department of Surgery and Orthopedics, Botucatu Medical School - Unesp, Av. Prof. Montenegro, Distrito de Rubião Junior, s/n, Botucatu, São Paulo 18618-687, Brazil. lourencao@fmb.unesp.br
Key Words	Intestinal neuronal dysplasia type B; Hyperplasia of the submucosal nerve plexus; Intestinal chronic constipation; Gastrointestinal neuromuscular diseases; Dysganglionosis
Core Tip	Intestinal neuronal dysplasia type B (IND-B) is a controversial entity among the gastrointestinal neuromuscular disorders. Chronic constipation is the most common clinical manifestation of patients. IND-B primarily affects young children and mimics Hirschsprung’s disease, but has its own histopathologic features characterized mainly by hyperplasia of the submucosal nerve plexus. Despite the intense scientific research in the last decades, there are still knowledge gaps regarding IND-B. This review critically discusses aspects related to the disease definitions, pathophysiology and genetics, epidemiology distribution, clinical presentation, diagnostic criteria and therapeutic possibilities of this still little-known organic cause of intestinal chronic constipation.
Publish Date	2016-08-01 11:49
Citation	Toledo de Arruda Lourenção PL, Terra SA, Ortolan EVP, Rodrigues MAM. Intestinal neuronal dysplasia type B: A still little known diagnosis for organic causes of intestinal chronic constipation. World J Gastrointest Pharmacol Ther 2016; 7(3): 397-405
URL	http://www.wjgnet.com/2150-5349/full/v7/i3/397.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i3.397

Full Article (PDF)	WJGPT-7-397.pdf
Full Article (Word)	WJGPT-7-397.doc
Manuscript File	24924-Review.docx
Answering Reviewers	24924-Answering reviewers.pdf
Audio Core Tip	24924-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	24924-Conflict-of-interest statement.pdf
Copyright License Agreement	24924-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	24924-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	24924-Language certificate.pdf
Peer-review Report	24924-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24924-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24924-Scientific misconduct check.pdf
Scientific Editor Work List	24924-Scientific editor work list.pdf