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Articles Published Processes
5/30/2016 5:39:00 PM | Browse: 1012 | Download: 1785
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Received |
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2016-02-15 09:48 |
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Peer-Review Started |
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2016-02-17 16:59 |
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To Make the First Decision |
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2016-03-21 08:34 |
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Return for Revision |
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2016-03-23 15:38 |
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Revised |
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2016-04-11 17:26 |
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Second Decision |
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2016-04-22 10:29 |
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Accepted by Journal Editor-in-Chief |
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2016-04-22 14:15 |
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Accepted by Executive Editor-in-Chief |
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2016-05-04 18:27 |
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Articles in Press |
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2016-05-04 18:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-05-09 09:21 |
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Typeset the Manuscript |
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2016-05-18 17:14 |
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Publish the Manuscript Online |
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2016-05-30 17:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ying-Ying Qiao, Xiao-Qin Liu, Chang-Qin Xu, Zheng Zhang and Hong-Wei Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Provincial Science and Technology Committee of China |
2014GGH218034 |
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| Corresponding Author |
Dr. Hong-Wei Xu, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Weiqi Road, Huai Yin District, Jinan 250021, Shandong Province, China. xu_hong_wei@sina.com |
| Key Words |
Interleukin-22; Acute severe pancreatitis; Lung injury; Anti-apoptosis gene; Signal transducer and activator of transcription 3 |
| Core Tip |
Interleukin-22 (IL-22) is recognized today as a key player in the antimicrobial defense, regeneration, and protection against damage. However, no reports have described the effects of IL-22 on acute severe pancreatitis (SAP)-associated lung injury. In this study, we found that IL-22 alleviated SAP-associated lung injury in mice by enhancing the expression of anti-apoptosis genes, such as Bcl-2 and Bcl-xL, through the STAT3 signaling pathway. Therefore, IL-22 and the components of STAT3 signaling pathway may be promising targets in the treatment of SAP-associated lung injury. |
| Publish Date |
2016-05-30 17:40 |
| Citation |
Qiao YY, Liu XQ, Xu CQ, Zhang Z, Xu HW. Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice. World J Gastroenterol 2016; 22(21): 5023-5032 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i21/5023.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i21.5023 |
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