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Articles Published Processes
6/21/2016 6:11:00 PM | Browse: 1004 | Download: 1663
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Received |
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2016-02-20 08:46 |
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Peer-Review Started |
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2016-02-20 08:56 |
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To Make the First Decision |
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2016-03-21 08:44 |
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Return for Revision |
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2016-03-23 16:28 |
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Revised |
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2016-04-11 21:48 |
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Second Decision |
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2016-04-28 09:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-05-04 18:33 |
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Articles in Press |
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2016-05-04 18:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-05-25 18:15 |
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Typeset the Manuscript |
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2016-06-02 09:47 |
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Publish the Manuscript Online |
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2016-06-21 18:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Zhong Sheng, Yu-Sheng Chen, Chuan-Tao Tu, Juan He, Bo Zhang and Wei-Dong Gao |
| Funding Agency and Grant Number |
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| Corresponding Author |
Wei-Dong Gao, MD, Associate Professor, Department of General Surgery, Fudan University affiliated Zhongshan Hospital, NO. 180 Fenglin Road, Shanghai 200032, China. gao.weidong@zs-hospital.sh.cn |
| Key Words |
MicroRNA-21; Protein kinase B; Colorectal cancer; Phosphatidylinositol 3-kinase; Phosphatase and tensin homolog |
| Core Tip |
RT-PCR and Western blot were applied to detect the expression level of microRNA-21 (miR-21) and Phosphatase gene (PTEN), including its downstream proteins protein kinase B (AKT) and phosphatidylinositol 3-kinase (PI3K) in colorectal cancer (CRC) cell lines, and to explore the regulatory mechanism of the expression of miR-21 in inhibiting CRC, respectively. Their associations were investigated to clarify whether one of the direct target genes of miR-21 is PTEN. The expression levels of miR-21, PTEN and its downstream proteins AKT and PI3K are regulated and controlled to manage the occurrence and progression of CRC. |
| Publish Date |
2016-06-21 18:11 |
| Citation |
Sheng WZ, Chen YS, Tu CT, He J, Zhang B, Gao WD. MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer. World J Gastroenterol 2016; 22(24): 5532-5539 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i24/5532.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i24.5532 |
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