Publication Name	World Journal of Gastroenterology
Manuscript ID	25055
Country	China

Received	2016-03-11 13:49
Peer-Review Started	2016-03-11 20:57
To Make the First Decision	2016-03-31 10:33
Return for Revision	2016-03-31 13:25
Revised	2016-04-25 16:24
Second Decision	2016-05-05 16:45
Accepted by Journal Editor-in-Chief	2016-05-05 20:56
Accepted by Company Editor-in-Chief	2016-05-23 16:51
Articles in Press	2016-05-23 16:51
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-05-28 08:06
Typeset the Manuscript	2016-06-01 15:23
Publish the Manuscript Online	2016-06-21 18:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Retrospective Cohort Study
Article Title	miR-422a is an independent prognostic factor and functions as a potential tumor suppressor in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Gui-Xi Zheng, Ai-Lin Qu, Yong-Mei Yang, Xin Zhang, Shou-Cai Zhang and Chuan-Xin Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81472025 Outstanding Young Scientist Research Award Fund of Shandong Province BS2014YY023 Projects of Medical and Health Technology Development Program of Shandong Province 2014WS0124 Science Foundation of Qilu Hospital of Shandong University 2015QLQN37 Fundamental Research of Shandong University and the National Key Clinical Medical Specialties Foundation
Corresponding Author	Chuan-Xin Wang, MD, PhD, Department of Clinical Laboratory, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan 250012, Shandong Province, China. cxwang@sdu.edu.cn
Key Words	Colorectal cancer; MicroRNA; miR-422a; Prognosis; In vitro function
Core Tip	In the present study, we found that miR-422a was dramatically reduced in colorectal cancer (CRC) tissues, and significantly correlated with local invasion and lymph node metastasis. miR-422a expression and clinical TNM stage were independent prognostic factors for overall survival in CRC patients. Furthermore, in vitro experiments showed that overexpression of miR-422a inhibited the proliferation, migration, and invasion of SW480 and HT-29 cells. These results indicated that down-regulation of miR-422a might serve as an independent prognosis factor in CRC, and miR-422a functions as a tumor suppressor and regulates progression of CRC.
Publish Date	2016-06-21 18:11
Citation	Zheng GX, Qu AL, Yang YM, Zhang X, Zhang SC, Wang CX. miR-422a is an independent prognostic factor and functions as a potential tumor suppressor in colorectal cancer. World J Gastroenterol 2016; 22(24): 5589-5597
URL	http://www.wjgnet.com/1007-9327/full/v22/i24/5589.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i24.5589

Full Article (PDF)	WJG-22-5589.pdf
Full Article (Word)	WJG-22-5589.doc
Manuscript File	25055-Review.doc
Answering Reviewers	25055-Answering reviewers.pdf
Audio Core Tip	25055-Audio core tip.wav
Biostatistics Review Certificate	25055-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25055-Conflict-of-interest statement.pdf
Copyright License Agreement	25055-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25055-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	25055-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	25055-Lanfuage certificate.pdf
Supplementary Material	Supplementary_Material_20160311112249.pdf
Peer-review Report	25055-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25055-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25055-Scientific misconduct check.pdf
Scientific Editor Work List	25055-Scientific editor work list.pdf