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6/14/2016 3:33:00 PM | Browse: 627 | Download: 954
Publication Name World Journal of Hepatology
Manuscript ID 25089
Country of Manuscript Source Denmark
Received
2016-02-22 08:21
Peer-Review Started
2016-02-22 16:26
To Make the First Decision
2016-03-23 11:05
Return for Revision
2016-03-24 10:27
Revised
2016-04-26 15:15
Second Decision
2016-05-16 08:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-06-02 15:40
Articles in Press
2016-06-02 15:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-06-03 09:41
Publish the Manuscript Online
2016-06-14 15:22
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Anti-CD163-dexamethasone conjugate inhibits the acute phase response to lipopolysaccharide in rats
Manuscript Source Invited Manuscript
All Author List Karen Louise Thomsen, Holger Jon Møller, Jonas Heilskov Graversen, Nils E Magnusson, Søren K Moestrup, Hendrik Vilstrup and Henning Grønbæk
Funding Agency and Grant Number
Funding Agency Grant Number
NOVO Nordisk foundation
Aarhus University Research Foundation
Clinical Institute, Aarhus University, Denmark
Corresponding author Karen Louise Thomsen, MD, PhD, Department of Hepatology and Gastroenterology, Aarhus Univer­sity Hospital, 44 Nørrebrogade, DK-8000 Aarhus C, Denmark. karethom@rm.dk
Keywords Acute phase response; Dexamethasone; Endotoxin; Hemoglobin scavenger receptor CD163; Cytokines; Inflammation; Rats
Core Tip We aimed to study the effect of a new anti-CD163-dexamethasone conjugate targeting activated macrophages on the hepatic acute phase response in rats. The central finding of the study was a reduction in liver mRNA and plasma levels of the acute phase protein a-2-macroglobulin, and plasma tumour necrosis factor-a and interleukin 6 by administration of the conjugate prior to a lipopolysaccharide-induced inflammatory res-ponse. This anti-acute phase effect exceeded that of the therapeutic dexamethasone dose and did not cause systemic adverse effects. Thus, the antibody conjugate may be a potential candidate in future anti-inflammatory macrophage-directed therapy, e.g., in liver diseases with Kupffer cells activation.
Publish Date 2016-06-14 15:22
Citation Thomsen KL, Møller HJ, Graversen JH, Magnusson NE, Moestrup SK, Vilstrup H, Grønbæk H. Anti-CD163-dexame­thasone conjugate inhibits the acute phase response to lipopoly­saccharide in rats. World J Hepatol 2016; 8(17): 726-730
Url http://www.wjgnet.com/1948-5182/full/v8/i17/726.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i17.726
Full Article (PDF) WJH-8-726.pdf
Full Article (Word) WJH-8-726.doc
Manuscript File 25089-Review.docx
Answering Reviewers 25089-Answering reviewers.pdf
Audio Core Tip 25089-Audio core tip.aif
Conflict-of-Interest Disclosure Form 25089-Conflict-of-interest statement.pdf
Copyright License Agreement 25089-Copyright assignment.pdf
Data Sharing Statement 25089-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 25089-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 25089-Institutional animal care and use committee statement.pdf
Peer-review Report 25089-Peer-review(s).pdf
Scientific Misconduct Check 25089-Scientific misconduct check.pdf
Scientific Editor Work List 25089-Scientific editor work list.pdf