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Articles Published Processes
6/14/2016 3:33:00 PM | Browse: 1624 | Download: 2422
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Received |
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2016-02-22 08:21 |
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Peer-Review Started |
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2016-02-22 16:26 |
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To Make the First Decision |
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2016-03-23 11:05 |
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Return for Revision |
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2016-03-24 10:27 |
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Revised |
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2016-04-26 15:15 |
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Second Decision |
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2016-05-16 08:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-06-02 15:40 |
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Articles in Press |
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2016-06-02 15:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-06-03 09:41 |
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Publish the Manuscript Online |
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2016-06-14 15:22 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-CD163-dexamethasone conjugate inhibits the acute phase response to lipopolysaccharide in rats
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Karen Louise Thomsen, Holger Jon Møller, Jonas Heilskov Graversen, Nils E Magnusson, Søren K Moestrup, Hendrik Vilstrup and Henning Grønbæk |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NOVO Nordisk foundation |
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| Aarhus University Research Foundation |
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| Clinical Institute, Aarhus University, Denmark |
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| Corresponding Author |
Karen Louise Thomsen, MD, PhD, Department of Hepatology and Gastroenterology, Aarhus University Hospital, 44 Nørrebrogade, DK-8000 Aarhus C,
Denmark. karethom@rm.dk
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| Key Words |
Acute phase response; Dexamethasone; Endotoxin; Hemoglobin scavenger receptor CD163; Cytokines; Inflammation; Rats |
| Core Tip |
We aimed to study the effect of a new anti-CD163-dexamethasone conjugate targeting activated macrophages on the hepatic acute phase response in rats. The central finding of the study was a reduction in liver mRNA and plasma levels of the acute phase protein a-2-macroglobulin, and plasma tumour necrosis factor-a and interleukin 6 by administration of the conjugate prior to a lipopolysaccharide-induced inflammatory res-ponse. This anti-acute phase effect exceeded that of the therapeutic dexamethasone dose and did not cause systemic adverse effects. Thus, the antibody conjugate may be a potential candidate in future anti-inflammatory macrophage-directed therapy, e.g., in liver diseases with Kupffer cells activation.
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| Publish Date |
2016-06-14 15:22 |
| Citation |
Thomsen KL, Møller HJ, Graversen JH, Magnusson NE, Moestrup SK, Vilstrup H, Grønbæk H. Anti-CD163-dexamethasone conjugate inhibits the acute phase response to lipopolysaccharide in rats. World J Hepatol 2016; 8(17): 726-730 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i17/726.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i17.726 |
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