Publication Name	World Journal of Critical Care Medicine
Manuscript ID	25105
Country	Netherlands

Received	2016-02-24 09:58
Peer-Review Started	2016-02-25 13:47
To Make the First Decision	2016-03-23 11:06
Return for Revision	2016-03-24 10:42
Revised	2016-04-07 04:02
Second Decision	2016-04-12 17:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-04-22 16:36
Articles in Press	2016-04-22 16:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-28 12:22
Publish the Manuscript Online	2016-08-02 21:40

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Systematic Reviews
Article Title	Predictive value of cytokines for developing complications after polytrauma
Manuscript Source	Invited Manuscript
All Author List	Anne-Britt E Dekker, Pieta Krijnen and Inger B Schipper
Funding Agency and Grant Number
Corresponding Author	Anne-Britt E Dekker, MD, Department of Trauma Surgery, Leiden University Medical Center, Postal Zone K6-R, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. a.e.dekker@lumc.nl
Key Words	Multiple trauma; Cytokine; Acute respiratory distress syndrome; Sepsis; Muli-organ dysfunction syndrome; Multi-organ failure
Core Tip	Early identification of patients at risk for developing complications is one of the most challenging problems in the therapy of multiple injuries. Close monitoring of cytokine secretion patterns could give physicians an impression of the individual risk for development of complications. Further, physicians are directed to the appropriate prophylactic treatment, as well as optimal timing of surgical interventions, thereby reducing “second hits” with subsequent risks of development of sepsis and multiorgan failure. This article provides an overview of the results from literature concerning posttraumatic immune alterations leading to various complications and death.
Publish Date	2016-08-02 21:40
Citation	Dekker ABE, Krijnen P, Schipper IB. Predictive value of cytokines for developing complications after polytrauma. World J Crit Care Med 2016; 5(3): 187-200
URL	http://www.wjgnet.com/2220-3141/full/v5/i3/187.htm
DOI	http://dx.doi.org/10.5492/wjccm.v5.i3.187

Full Article (PDF)	WJCCM-5-187.pdf
Full Article (Word)	WJCCM-5-187.doc
Manuscript File	25105-Review.docx
Answering Reviewers	25105-Answering reviewers.pdf
Audio Core Tip	25105-Audio core tip.mp3
Biostatistics Review Certificate	25105-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25105-Conflict-of-interest statement.pdf
Copyright License Agreement	25105-Copyright assignment.pdf
Peer-review Report	25105-Peer-review(s).pdf
Scientific Misconduct Check	25105-Scientific misconduct check.pdf
Scientific Editor Work List	25105-Scientific editor work list.pdf