Publication Name	World Journal of Gastroenterology
Manuscript ID	25156
Country	Spain

Received	2016-02-25 08:34
Peer-Review Started	2016-02-25 09:38
To Make the First Decision	2016-03-21 09:00
Return for Revision	2016-03-21 10:22
Revised	2016-03-30 00:00
Second Decision	2016-04-08 17:29
Accepted by Journal Editor-in-Chief	2016-04-11 11:43
Accepted by Executive Editor-in-Chief	2016-04-15 14:11
Articles in Press	2016-04-15 14:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-20 10:10
Publish the Manuscript Online	2016-05-04 10:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Peer-review started: February 25, 2016
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Thrombin activation and liver inflammation in advanced hepatitis C virus infection
Manuscript Source	Invited Manuscript
All Author List	Emilio González-Reimers, Geraldine Quintero-Platt, Candelaria Martín-González, Onán Pérez-Hernández, Lucía Romero-Acevedo and Francisco Santolaria-Fernández
Funding Agency and Grant Number
Corresponding Author	Emilio González-Reimers, MD, PhD, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Ofra s/n, San Cristóbal de La Laguna, Tenerife, 38320 Canary Islands, Spain. egonrey@ull.es
Key Words	Coagulation; Liver cirrhosis; Hepatitis C virus; Fibrogenesis; Parenchymal extinction; Portal thrombosis; Protein C
Core Tip	Liver cirrhosis may be considered a prothrombotic condition despite it being associated with a low platelet count and deranged synthesis of clotting factors. When hepatitis C virus (HCV) is the etiological factor of liver cirrhosis, intrahepatic coagulation may be enhanced by several direct actions of HCV on the clotting system, platelet aggregation, and altered anticoagulation. The excessive thrombin generation may be related to increased fibrogenesis both by a direct effect of thrombin on hepatic stellate cells and fibrosis related to ischemic parenchymal extinction.
Publish Date	2016-05-04 10:08
Citation	González-Reimers E, Quintero-Platt G, Martín-Gonzále C, Pérez-Hernández O, Romero-Acevedo L, Santolaria-Fernández F. Thrombin activation and liver inflammation in advanced hepatitis C virus infection. World J Gastroenterol 2016; 22(18): 4427-4437
URL	http://www.wjgnet.com/1007-9327/full/v22/i18/4427.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i18.4427

Full Article (PDF)	WJG-22-4427.pdf
Full Article (Word)	WJG-22-4427.doc
Manuscript File	25156-Review.doc
Answering Reviewers	25156-Answering review(s).pdf
Audio Core Tip	25156-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25156-Conflict-of-interest statement.pdf
Copyright License Agreement	25156-Copyright assignment.pdf
Peer-review Report	25156-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25156-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25156-Scientific misconduct check.pdf
Scientific Editor Work List	25156-Scientific editor work list.pdf