Publication Name	World Journal of Gastroenterology
Manuscript ID	2519
Country	Brazil

Received	2013-02-25 20:06
Peer-Review Started	2013-02-26 15:29
To Make the First Decision	2013-04-03 09:10
Return for Revision	2013-04-12 09:56
Revised	2013-05-10 01:59
Second Decision	2013-06-19 12:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-20 00:53
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-28 09:59
Publish the Manuscript Online	2013-10-15 17:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Autobiography
Article Title	Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats
Manuscript Source	Invited Manuscript
All Author List	Paulo Emilio Botura Ferreira, Cláudia Regina Pinheiro Lopes, Angela Maria Pereira Alves, Éder Paulo Belato Alves, David Robert Linden, Jacqueline Nelisis Zanoni and Nilza Cristina Buttow
Funding Agency and Grant Number	Funding Agency Grant Number Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, Brasil NIH grant DK76665
Corresponding Author	Nilza Cristina Buttow, PhD, Department of Morphological Sciences, Universidade Estadual de Maringá, Av. Colombo, 5790 Bloco H-79, Maringá, PR. CEP 87020-900, Brazil. ncbuttow@gmail.com
Key Words	Diabetes; Myenteric plexus; Neuroprotection; Neuronal nitric oxide synthase; Vasoactive intestinal polypeptide; Enteric glia
Core Tip	The present study is the first to report a neuroprotective effect of the flavonoid quercetin in the general population of enteric neurons in the cecum of rats with experimental diabetes mellitus. Quercetin did not reduce the loss of nitrergic neurons in the diabetic rats. This observation suggests that selective changes in the neurochemical code of enteric neurons occur in the presence of quercetin. We propose a causal link between the area and number of glial cells and the size of VIP-IR (reduction in varicosity population) varicosities. Although this link is not fully understood, these observations provide a basis for further studies to clarify the link between glia and VIP-IR varicosities.
Publish Date	2013-10-15 17:26
Citation	Ferreira PEB, Lopes CRP, Alves AMP, Alves éPB, Linden DR, Zanoni JN, Buttow NC. Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats. World J Gastroenterol 2013; 19(38): 6416-6426
URL	http://www.wjgnet.com/1007-9327/full/v19/i38/6416.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i38.6416

Full Article (PDF)	WJG-19-6416.pdf
Manuscript File	2519-review.doc
Answering Reviewers	2519-Answering reviewers.pdf
Copyright License Agreement	2519-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	2519-Language certificate.doc
Peer-review Report	2519-Peer review(s).pdf
Scientific Editor Work List	2519-Scientific editor work list.doc