Publication Name	World Journal of Biological Chemistry
Manuscript ID	25195
Country	United States

Received	2016-02-27 14:23
Peer-Review Started	2016-02-27 18:41
To Make the First Decision	2016-03-23 11:08
Return for Revision	2016-03-24 11:22
Revised	2016-04-14 05:21
Second Decision	2016-04-26 16:26
Accepted by Journal Editor-in-Chief	2016-04-26 19:16
Accepted by Executive Editor-in-Chief	2016-07-13 12:20
Articles in Press	2016-07-13 12:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-19 16:22
Publish the Manuscript Online	2016-08-22 14:22

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters
Manuscript Source	Invited Manuscript
All Author List	Zhibo Ma, Mo Li, Sharmila Roy, Kevin J Liu, Matthew L Romine, Derrick C Lane, Sapna K Patel and Haini N Cai
Funding Agency and Grant Number
Corresponding Author	Haini N Cai, PhD, Associate Professor, Department of Cellular Biology, University of Georgia, 1000 Cedar Street, Athens, GA 30602, United States. hcai@uga.edu
Key Words	Chromatin boundary element; Insulator; CTCF; Chromatin loop domains; Drosophila; Hox genes
Core Tip	Genomic organization in higher eukaryotes needs to fulfill at least three distinct functions: Gene compaction, gene insulation and gene regulation. Chromatin loops appear to be a common structural unit that serves all these functions. A recent study has characterized a series of chromatin boundary elements (CBEs) in the Drosophila Hox cluster. Selective and dynamic interactions between these CBEs tether chromatin loops that not only insulate neighboring genes, but also organize enhancer traffic to regulate gene expression during development.
Publish Date	2016-08-22 14:22
Citation	Ma Z, Li M, Roy S, Liu KJ, Romine ML, Lane DC, Patel SK, Cai HN. Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters. World J Biol Chem 2016; 7(3): 223-230
URL	http://www.wjgnet.com/1949-8454/full/v7/i3/223.htm
DOI	http://dx.doi.org/10.4331/wjbc.v7.i3.223

Full Article (PDF)	WJBC-7-223.pdf
Full Article (Word)	WJBC-7-223.doc
Manuscript File	25195-Review.docx
Answering Reviewers	25195-Answering reviewers.pdf
Audio Core Tip	25195-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25195-Conflict-of-interest statement.pdf
Copyright License Agreement	25195-Copyright assignment.pdf
Supplementary Material	25195-Supplementary material.pdf
Peer-review Report	25195-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25195-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25195-Scientific misconduct check.pdf
Scientific Editor Work List	25195-Scientific editor work list.pdf