| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Hepatitis C virus cures after direct acting antiviral-related drug-induced liver injury: Case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yaakov Hasin, Shimon Shteingart, Harel Dahari, Inna Gafanovich, Sharon Floru, Marius Braun, Amir Shlomai, Anthony Verstandig, Ilana Dery, Susan L Uprichard, Scott J Cotler and Yoav Lurie |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH |
R01-AI078881 |
|
| Corresponding Author |
Dr. Yoav Luria, Liver Unit, Digestive Disease Institute, Shaare Zedek Medical Center, Shmu’el Bait St 12, Jerusalem 9103102, Israel. yoavtalitami@gmail.com |
| Key Words |
Direct antiviral agent; Drug-induced liver injury; Hepatitis C; Mathematical modeling; Sustained virological response; Viral kinetics |
| Core Tip |
To the best of our knowledge, this is the first report of hepatic decompensation in a hepatitis C patient with Child Pugh class A cirrhosis due to treatment with Paritaprevir, Ombitasvir, Dasabuvir, Ritonavir and Ribavirin (PODr + R). Liver aminotransferase levels did not increase prior to decompensation, depriving us of our usual alarm signs heralding hepatic decompensation. The patient achieved sustained virologic response despite very early discontinuation of therapy (day 24). |
| Publish Date |
2016-07-13 14:42 |
| Citation |
Hasin Y, Shteingart S, Dahari H, Gafanovich I, Floru S, Braun M, Shlomai A, Verstandig A, Dery I, Uprichard SL, Cotler SJ, Lurie Y. Hepatitis C virus cures after direct acting antiviral-related drug-induced liver injury: Case report. World J Hepatol 2016; 8(20): 858-862 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i20/858.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i20.858 |
