| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Procalcitonin, and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Bashar M Attar, Christopher M Moore, Magdalena George, Nicolae Ion-Nedelcu, Rafael Turbay, Annamma Zachariah, Guiliano Ramadori, Jawed Fareed and David H Van Thiel |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Bashar M Attar, MD, PhD, AGAF, FACP, FACG, FASGE, Professor of Medicine, Division of Gastroenterology and Hepatology, John H Stroger Hospital of Cook County, 1901 W. Harrison Street, Admin. bldg, Suite 1450, Chicago, IL 60612, United States. battar@rush.edu
|
| Key Words |
Ascites; Bacterial translocation; Inflammatory markers; Procalcitonin; Cirrhosis |
| Core Tip |
Procalcitonin received much attention as a serum marker in differentiating sepsis from systemic inflammatory response syndrome and bacterial sepsis. Procalcitonin significance in assessing ascitic fluid inflammation and/or infection is less well characterized. This study demonstrates that non-infected cirrhotics with ascites vs those without ascites manifest peri-peritoneal based immune response mediated by a constellation of pro- and anti-inflammatory protein markers and procalcitonin. This peri-peritoneal response is distinct from the systemic immune response to the underlying hepatic disease process. Its recognition can potentially determine the likelihood for future adverse events like spontaneous bacterial peritonitis, the hepato-renal syndrome and impending death.
|
| Publish Date |
2014-03-06 14:13 |
| Citation |
Attar BM, Moore CM, George M, Ion-Nedelcu N, Turbay R, Zachariah A, Ramadori G, Fareed J, Van Thiel DH. Procalcitonin, and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites. World J Gastroenterol 2014; 20(9): 2374-2382 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i9/2374.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i9.2374 |
