Publication Name	World Journal of Gastroenterology
Manuscript ID	2528
Country	United States

Received	2013-02-26 09:43
Peer-Review Started	2013-02-27 10:18
First Decision by Editorial Office Director
Return for Revision	2013-03-25 11:53
Revised	2013-04-23 08:05
Publication Fee Transferred
Second Decision by Editor	2013-06-03 16:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-06-04 09:23
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-20 14:56
Publish the Manuscript Online	2014-03-06 14:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Procalcitonin, and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites
Manuscript Source	Invited Manuscript
All Author List	Bashar M Attar, Christopher M Moore, Magdalena George, Nicolae Ion-Nedelcu, Rafael Turbay, Annamma Zachariah, Guiliano Ramadori, Jawed Fareed and David H Van Thiel
Funding Agency and Grant Number
Corresponding Author	Bashar M Attar, MD, PhD, AGAF, FACP, FACG, FASGE, Professor of Medicine, Division of Gastroenterology and Hepatology, John H Stroger Hospital of Cook County, 1901 W. Harrison Street, Admin. bldg, Suite 1450, Chicago, IL 60612, United States. battar@rush.edu
Key Words	Ascites; Bacterial translocation; Inflammatory markers; Procalcitonin; Cirrhosis
Core Tip	Procalcitonin received much attention as a serum marker in differentiating sepsis from systemic inflammatory response syndrome and bacterial sepsis. Procalcitonin significance in assessing ascitic fluid inflammation and/or infection is less well characterized. This study demonstrates that non-infected cirrhotics with ascites vs those without ascites manifest peri-peritoneal based immune response mediated by a constellation of pro- and anti-inflammatory protein markers and procalcitonin. This peri-peritoneal response is distinct from the systemic immune response to the underlying hepatic disease process. Its recognition can potentially determine the likelihood for future adverse events like spontaneous bacterial peritonitis, the hepato-renal syndrome and impending death.
Publish Date	2014-03-06 14:13
Citation	Attar BM, Moore CM, George M, Ion-Nedelcu N, Turbay R, Zachariah A, Ramadori G, Fareed J, Van Thiel DH. Procalcitonin, and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites. World J Gastroenterol 2014; 20(9): 2374-2382
URL	http://www.wjgnet.com/1007-9327/full/v20/i9/2374.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i9.2374

Full Article (PDF)	WJG-20-2374.pdf
Full Article (Word)	WJG-20-2374.doc
Manuscript File	2528-Review.doc
Answering Reviewers	2528-Answering reviewers.pdf
Biostatistics Review Certificate	Document will be provided upon approval of manuscript.docx
Copyright License Agreement	2528-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Document will be provided upon approval of manuscript.docx
Peer-review Report	2528-Peer reviews.pdf
Scientific Editor Work List	2528-Scientific editor work list.doc