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Articles Published Processes
7/4/2016 2:42:00 PM | Browse: 997 | Download: 2259
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Received |
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2016-03-03 08:56 |
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Peer-Review Started |
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2016-03-04 11:06 |
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To Make the First Decision |
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2016-04-01 08:05 |
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Return for Revision |
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2016-04-01 16:55 |
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Revised |
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2016-04-12 08:54 |
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Second Decision |
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2016-04-25 13:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-05-04 18:07 |
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Articles in Press |
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2016-05-04 18:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-05-17 09:21 |
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Typeset the Manuscript |
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2016-05-27 16:22 |
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Publish the Manuscript Online |
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2016-07-04 14:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Urotensin Ⅱ-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in HepG2 cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying-Ying Li, Zheng-Ming Shi, Xiao-Yong Yu, Ping Feng and Xue-Jiang Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81272757 |
| Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges under Beijing Municipalit |
IDHT20150502 |
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| Corresponding Author |
Xue-Jiang Wang, Professor, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing 100069, China. xjwang@ccmu.edu.cn
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| Key Words |
Urotensin Ⅱ; Insulin resistance; NADPH oxidase; Reactive oxygen species; HepG2 cells |
| Core Tip |
We report our results on urotensin Ⅱ (UII) in a newly developed insulin resistance model and the possible mechanisms involved. Exposure to UII may contribute to oxidative damage via the NADPH oxidase pathway and enhance the phosphorylation of c-Jun N-terminal kinase, which is associated with insulin signal transduction pathways. These may be the underlying mechanisms of UII-mediated insulin resistance in HepG2 cells. These findings confirm the important role of UII in hepatic insulin resistance, which shed light on new insight into hepatic insulin resistance.
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| Publish Date |
2016-07-04 14:42 |
| Citation |
Li YY, Shi ZM, Yu XY, Feng P, Wang XJ. Urotensin Ⅱ-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in HepG2 cells. World J Gastroenterol 2016; 22(25): 5769-5779 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i25/5769.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i25.5769 |
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