Publication Name	World Journal of Gastroenterology
Manuscript ID	25296
Country	China

Received	2016-03-03 08:56
Peer-Review Started	2016-03-04 11:06
First Decision by Editorial Office Director
Return for Revision	2016-04-01 16:55
Revised	2016-04-12 08:54
Publication Fee Transferred
Second Decision by Editor	2016-04-25 13:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-05-04 18:07
Articles in Press	2016-05-04 18:07
Edit the Manuscript by Language Editor	2016-05-17 09:21
Typeset the Manuscript	2016-05-27 16:22
Publish the Manuscript Online	2016-07-04 14:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Urotensin Ⅱ-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in HepG2 cells
Manuscript Source	Unsolicited Manuscript
All Author List	Ying-Ying Li, Zheng-Ming Shi, Xiao-Yong Yu, Ping Feng and Xue-Jiang Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81272757 Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges under Beijing Municipalit IDHT20150502
Corresponding Author	Xue-Jiang Wang, Professor, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing 100069, China. xjwang@ccmu.edu.cn
Key Words	Urotensin Ⅱ; Insulin resistance; NADPH oxidase; Reactive oxygen species; HepG2 cells
Core Tip	We report our results on urotensin Ⅱ (UII) in a newly developed insulin resistance model and the possible mechanisms involved. Exposure to UII may contribute to oxidative damage via the NADPH oxidase pathway and enhance the phosphorylation of c-Jun N-terminal kinase, which is associated with insulin signal transduction pathways. These may be the underlying mechanisms of UII-mediated insulin resistance in HepG2 cells. These findings confirm the important role of UII in hepatic insulin resistance, which shed light on new insight into hepatic insulin resistance.
Publish Date	2016-07-04 14:42
Citation	Li YY, Shi ZM, Yu XY, Feng P, Wang XJ. Urotensin Ⅱ-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in HepG2 cells. World J Gastroenterol 2016; 22(25): 5769-5779
URL	http://www.wjgnet.com/1007-9327/full/v22/i25/5769.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i25.5769

Full Article (PDF)	WJG-22-5769.pdf
Full Article (Word)	WJG-22-5769.doc
Manuscript File	25296-Review.docx
Answering Reviewers	25296-Answering reviewers.pdf
Audio Core Tip	25296-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	25296-Conflict-of-interest statement.pdf
Copyright License Agreement	25296-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25296-Language certificate.pdf
Supplementary Material	25296-Supplementary materials.pdf
Peer-review Report	25296-Peer-review(s).pdf
Scientific Misconduct Check	25296-Scientific misconduct check.pdf
Scientific Editor Work List	25296-Scientific editor work list.pdf