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Articles Published Processes
5/20/2016 11:59:00 AM | Browse: 1219 | Download: 2034
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Received |
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2016-03-04 09:14 |
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Peer-Review Started |
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2016-03-04 15:46 |
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To Make the First Decision |
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2016-03-21 14:04 |
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Return for Revision |
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2016-03-22 09:12 |
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Revised |
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2016-04-04 21:59 |
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Second Decision |
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2016-04-06 16:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-04-18 11:58 |
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Articles in Press |
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2016-04-18 11:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-06 16:01 |
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Publish the Manuscript Online |
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2016-05-20 11:59 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Azhar Maqbool, Emma J Spary, Iain W Manfield, Michaela Ruhmann, Lorena Zuliani-Alvarez, Filomena O Gamboa-Esteves, Karen E Porter, Mark J Drinkhill, Kim S Midwood and Neil A Turner |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| British Heart Foundation |
CH/92005 |
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| Corresponding Author |
Azhar Maqbool, PhD, Lecturer in Cardiovascular Medicine, Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Clarendon Way, Leeds LS2 9JT, United Kingdom. cvsam@leeds.ac.uk |
| Key Words |
Tenascin C; Matrix metalloproteinase; Toll-like receptor; Interleukin-6; Cardiac fibroblasts |
| Core Tip |
Tenascin C (TNC) is transiently expressed in cardiac tissue following acute myocardial infarction (MI) and MI patients with higher serum TNC levels have worse long term prognosis. This suggests that TNC is important in ventricular remodelling, although a functional role in this process is unclear. We report that TNC stimulates interleukin-6 synthesis in cardiac myofibroblasts, an effect mediated by toll-like receptor 4. As a growing body of evidence suggests that prolongation of the post-infarction inflammatory response results in worse remodelling and dysfunction this important observation may in part explain the mechanism by which TNC induces maladaptive ventricular remodelling following MI. |
| Publish Date |
2016-05-20 11:59 |
| Citation |
Maqbool A, Spary EJ, Manfield IW, Ruhmann M, Zuliani-Alvarez L, Gamboa-Esteves FO, Porter KE, Drinkhill MJ, Midwood KS, Turner NA. Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4. World J Cardiol 2016; 8(5): 340-350 |
| URL |
http://www.wjgnet.com/1949-8462/full/v8/i5/340.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v8.i5.340 |
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