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6/21/2016 6:11:00 PM | Browse: 460 | Download: 1185
Publication Name World Journal of Gastroenterology
Manuscript ID 25321
Country/Territory China
Received
2016-03-04 08:57
Peer-Review Started
2016-03-04 14:51
To Make the First Decision
2016-04-01 08:06
Return for Revision
2016-04-01 17:10
Revised
2016-04-10 20:53
Second Decision
2016-04-13 07:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-04-20 14:21
Articles in Press
2016-04-20 14:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-05-30 23:49
Typeset the Manuscript
2016-06-02 16:58
Publish the Manuscript Online
2016-06-21 18:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Case Report
Article Title Successful treatment of ileal ulcers caused by immunosuppressants in two organ transplant recipients
Manuscript Source Unsolicited Manuscript
All Author List Yun-Wei Guo, Hua-Ying Gu, Kodjo-Kunale Abassa, Xian-Yi Lin and Xiu-Qing Wei
Funding Agency and Grant Number
Funding Agency Grant Number
Guangdong Science and Technology Program 2012B061700072
Corresponding author Xiu-Qing Wei, MD, PhD, Professor, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou 510630, Guangdong Province, China. wei-xiuqing@163.com
Keywords Ileal ulcers; Liver transplantation; Kidney transplantation; Sirolimus; Tacrolimus
Core Tip There are few reports available on ileal ulcers caused by immunosuppressants. Herein, we report a liver transplant recipient and a renal transplant recipient who had multiple large ulcers in the distal ileum and ileocecal valve. Ulcers rapidly healed after withdrawal of sirolimus or tacrolimus and administration of thalidomide. No lymphoma, tuberculosis, or infection of cytomegalovirus, Epstein-Barr virus, or fungus was found in either patient. There was no recurrence of ulcers or organ rejection. In some post-transplantation cases with ileal ulcers, sirolimus or tacrolimus should be considered as a risk factor because of their inhibitory effects on wound healing. Withdrawing them or switching to other immunosuppressants might be effective.
Publish Date 2016-06-21 18:11
Citation Guo YW, Gu HY, Abassa KK, Lin XY, Wei XQ. Successful treatment of ileal ulcers caused by immunosuppressants in two organ transplant recipients. World J Gastroenterol 2016; 22(24): 5616-5622
Url http://www.wjgnet.com/1007-9327/full/v22/i24/5616.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i24.5616
Full Article (PDF) WJG-22-5616.pdf
Full Article (Word) WJG-22-5616.doc
Manuscript File 25321-Review.docx
Answering Reviewers 25321-Answering reviewers.pdf
Audio Core Tip 25321-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 25321-Conflict-of-interest statement.pdf
Copyright License Agreement 25321-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 25321-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160303224002.pdf
Institutional Review Board Approval Form or Document 25321-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate Editing_Certificate_20160303224120.pdf
Peer-review Report 25321-Peer-review(s).pdf
Scientific Misconduct Check 25321-Scientific misconduct check.pdf
Scientific Editor Work List 25321-Scientific editor work list.pdf