Publication Name	World Journal of Respirology
Manuscript ID	25324
Country	Greece

Received	2016-03-04 08:51
Peer-Review Started	2016-03-04 16:56
To Make the First Decision	2016-04-14 16:47
Return for Revision	2016-04-15 14:41
Revised	2016-04-19 00:00
Second Decision	2016-05-05 17:31
Accepted by Journal Editor-in-Chief	2016-05-06 02:22
Accepted by Executive Editor-in-Chief	2016-05-27 10:43
Articles in Press	2016-05-27 10:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-12 11:55
Publish the Manuscript Online	2016-07-19 08:57

ISSN	2218-6255 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Respiratory System
Manuscript Type	Editorial
Article Title	Asthma-chronic obstructive pulmonary disease overlap syndrome: A diagnostic puzzle for the clinicians
Manuscript Source	Invited Manuscript
All Author List	Ourania Koltsida, Antonia Koutsoukou, Nikolaos G Koulouris and Nikoletta Rovina
Funding Agency and Grant Number
Corresponding Author	Nikoletta Rovina, MD, PhD, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens Medical School, “Sotiria” Hospital for Chest Diseases, 152 Mesogeion Ave, 11527 Athens, Greece. nikrovina@med.uoa.gr
Key Words	Asthma; Chronic obstructive pulmonary disease; Asthma-chronic obstructive pulmonary disease overlap syndrome; Diagnostic challenges; Therapeutic dilemmas
Core Tip	Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) represents a diagnostic challenge in the clinical practice, since there is lack of specific indicators to distinguish it from asthma or COPD, and moreover, genetic risk factors, underlying pathology and molecular pathways, clinical characteristics, therapeutic interventions, response to treatment and prognosis are poorly described. Combination therapy with ICS/LABA or LAMA, or newly developed specific anti-eosinophil therapies and treatments specifically targeting neutrophils might be of relevance in the management of ACOS. More studies are needed in order to clarify the underlying mechanisms, the clinical aspects and the prognosis of ACOS.
Publish Date	2016-07-19 08:57
Citation	Koltsida O, Koutsoukou A, Koulouris NG, Rovina N. Asthma-chronic obstructive pulmonary disease overlap syndrome: A diagnostic puzzle for the clinicians. World J Respirol 2016; 6(2): 54-56
URL	http://www.wjgnet.com/2218-6255/full/v6/i2/54.htm
DOI	http://dx.doi.org/10.5320/wjr.v6.i2.54

Full Article (PDF)	WJR-6-54.pdf
Full Article (Word)	WJR-6-54.doc
Manuscript File	25324-Review.docx
Answering Reviewers	25324-Answering reviewers.pdf
Audio Core Tip	25324-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25324-Conflict-of-interest statement.pdf
Copyright License Agreement	25324-Copyright assignment.pdf
Peer-review Report	25324-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25324-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25324-Scientific misconduct check.pdf
Scientific Editor Work List	25324-Scientific editor work list.pdf