Publication Name	World Journal of Gastroenterology
Manuscript ID	25362
Country	China

Received	2016-04-13 09:18
Peer-Review Started	2016-04-14 09:10
To Make the First Decision	2016-08-29 09:17
Return for Revision	2016-08-29 10:34
Revised	2016-09-07 11:28
Second Decision	2016-09-30 17:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-10-10 17:35
Articles in Press	2016-10-10 17:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-10-21 17:52
Typeset the Manuscript	2016-11-09 15:56
Publish the Manuscript Online	2016-11-18 15:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Na+/HCO3- cotransporter is expressed on β and α cells during rat pancreatic development
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Hua Cao, Cheng-Cai Xia, Zhao-Chun Shi, Ning Wang, Zheng-Hua Gu, Li-Zhi Yu, Qi Wan and Wei De
Funding Agency and Grant Number	Funding Agency Grant Number Development of Medical Science and Technology Project of Jiangsu Province YKK13205
Corresponding Author	Wei De, PhD, Professor of Biochemistry, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. dewei@njmu.edu.cn
Key Words	Pancreatic development; β cells; α cells; Na+/HCO3- cotransporter; Immunolocalization
Core Tip	This manuscript demonstrated that Na+/HCO3- cotransporter (NBC1) was present in the plasma membrane of β and α cells as well as in the basolateral membrane of acinar cells in rat developing pancreas by immuno-fluorescence detection. NBC1 mRNA and protein were diversely expressed in the pancreas at different developmental stages by reverse transcription polymerase chain reaction and Western blot analysis. The result suggests that it may exert its functions in pancreatic development especially islet cell growth through HCO3- transport and pH regulation.
Publish Date	2016-11-18 15:13
Citation	Cao LH, Xia CC, Shi ZC, Wang N, Gu ZH, Yu LZ, Wan Q, De W. Na+/HCO3- cotransporter is expressed on β and α cells during rat pancreatic development. World J Gastroenterol 2016; 22(43): 9525-9533
URL	http://www.wjgnet.com/1007-9327/full/v22/i43/9525.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i43.9525

Full Article (PDF)	WJG-22-9525.pdf
Full Article (Word)	WJG-22-9525.doc
Manuscript File	25362-Review.docx
Answering Reviewers	25362-Answering reviewers.pdf
Audio Core Tip	25362-Audio core tip.mp3
Biostatistics Review Certificate	25362-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25362-Conflict-of-interest statement.pdf
Copyright License Agreement	25362-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25362-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	25362-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	25362-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	25362-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160412224251.pdf
Peer-review Report	25362-Peer-review(s).pdf
Scientific Misconduct Check	25362-Scientific misconduct check.pdf
Scientific Editor Work List	25362-Scientific editor work list.pdf