Publication Name	World Journal of Nephrology
Manuscript ID	25386
Country	Italy

Received	2016-03-07 08:40
Peer-Review Started	2016-03-09 15:52
To Make the First Decision	2016-03-25 14:42
Return for Revision	2016-03-25 20:01
Revised	2016-03-31 23:18
Second Decision	2016-05-10 14:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-05-27 11:09
Articles in Press	2016-05-27 11:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-20 17:24
Publish the Manuscript Online	2016-06-29 09:02

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori and Giuseppina Rosso
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, MD, Department of Renal Transplantation, Careggi University Hospital, viale Pieraccini 18, 50139 Florence, Italy. maurizio.salvadori1@gmail.com
Key Words	Glomerulonephritis reclassification; Dense deposit disease; Membranoproliferative glomerulonephritis; C3 glomerulopathies; Targeting complement pathways; Complement dysregulation
Core Tip	The complement pathway dysregulation has been recognized as the main cause of some membrano?proliferative glomerulonephritis (MPGNs). This fact is at the basis of the new classification of the disease and of the findings of new entities as the complement factor H related protein nephropathy. Genetic studies as well as improvement in proteomics allowed recognizing the complement dysregulation as the cause of some renal diseases as the MPGN and the atypical hemolytic uremic syndrome that may be considered as strictly related diseases. The anti-complement drugs represent a new approach in the treatment of these diseases and their use in larger evidence based randomized trials is required.
Publish Date	2016-06-29 09:02
Citation	Salvadori M, Rosso G. Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN. World J Nephrol 2016; 5(4): 308-320
URL	http://www.wjgnet.com/2220-6124/full/v5/i4/308.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i4.308

Full Article (PDF)	WJN-5-308.pdf
Full Article (Word)	WJN-5-308.doc
Manuscript File	25386-Review.docx
Answering Reviewers	25386-Answering reviewers.pdf
Audio Core Tip	25386-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25386-Conflict-of-interest statement.pdf
Copyright License Agreement	25386-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25386-Language certificate.pdf
Peer-review Report	25386-Peer-review(s).pdf
Scientific Misconduct Check	25386-Scientific misconduct check.pdf
Scientific Editor Work List	25386-Scientific editor work list.pdf