Publication Name	World Journal of Gastroenterology
Manuscript ID	2540
Country	United Kingdom

Received	2013-02-27 09:17
Peer-Review Started	2013-02-27 16:33
To Make the First Decision	2013-03-25 15:24
Return for Revision	2013-04-01 14:04
Revised	2013-05-10 06:39
Second Decision	2013-07-05 10:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-05 12:32
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-21 10:23
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Immunohistochemical assessment of NY-ESO-1 expression in esophageal adenocarcinoma resection specimens
Manuscript Source	Invited Manuscript
All Author List	Stephen J Hayes, Keng Ngee Hng, Peter Clark, Fiona Thistlethwaite, Robert E Hawkins and Yeng Ang
Funding Agency and Grant Number
Corresponding Author	Dr. Stephen J Hayes, Department of Histopathology, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, United Kingdom. stephen.hayes@srft.nhs.uk
Key Words	Esophageal adenocarcinoma; Immunohistochemistry; NY-ESO-1; Stem cells; Vesicle trafficking
Core Tip	NY-ESO-1 is a cancer-testis antigen of particular interest, as it displays exceptional immunogenicity - hence, it is an attractive candidate for cancer vaccine therapy. To our knowledge, we have demonstrated for the first time, using immunohistochemistry, strong and diffuse nuclear and cytoplasmic expression for NY-ESO-1 in a cohort of esophageal adenocarcinoma cases. We have also demonstrated NY-ESO-1 expression in normal tissues other than germ cells, albeit as dot-positivity, indicating shared protein expression and association between primitive germ cells and somatic cells. We further relate our findings to proposed locations of stem cells in the esophagus and large bowel.
Publish Date	2014-04-14 10:49
Citation	Hayes SJ, Hng KN, Clark P, Thistlethwaite F, Hawkins RE, Ang Y. Immunohistochemical assessment of NY-ESO-1 expression in esophageal adenocarcinoma resection specimens. World J Gastroenterol 2014; 20(14): 4011-4016
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/4011.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.4011

Full Article (PDF)	WJG-20-4011.pdf
Full Article (Word)	WJG-20-4011.doc
Manuscript File	2540-Review.doc
Answering Reviewers	2540-Answering reviewers.pdf
Copyright License Agreement	2540-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	11 NW 0632 Ang Further Information Favourable Opinion.pdf
Peer-review Report	2540-Peer reviews.pdf
Scientific Editor Work List	2540-Scientific editor work list.doc