Publication Name	World Journal of Gastroenterology
Manuscript ID	25422
Country	United Kingdom

Received	2016-03-09 09:24
Peer-Review Started	2016-03-10 20:49
First Decision by Editorial Office Director
Return for Revision	2016-05-12 10:52
Revised	2016-05-28 00:16
Publication Fee Transferred
Second Decision by Editor	2016-06-20 08:15
Second Decision by Editor-in-Chief	2016-06-21 19:51
Final Decision by Editorial Office Director	2016-06-28 15:48
Articles in Press	2016-06-28 15:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-27 11:43
Publish the Manuscript Online	2016-08-04 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Mechanisms of triglyceride metabolism in patients with bile acid diarrhea
Manuscript Source	Invited Manuscript
All Author List	Nidhi Midhu Sagar, Michael McFarlane, Chuka Nwokolo, Karna Dev Bardhan and Ramesh Pulendran Arasaradnam
Funding Agency and Grant Number
Corresponding Author	Ramesh Arasaradnam, PhD, FRCP, FEBGH, Professor, Department of Gastroenterology, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, United Kingdom. r.arasaradnam@warwick.ac.uk
Key Words	Bile acids; Bile acid diarrhea; Triglycerides; Farnesoid X receptor
Core Tip	Bile acids are essential for the absorption of dietary lipids. The farnesoid X receptor (FXR) has a crucial role in triglyceride metabolism through regulating hepatic de novo lipogenesis and modulating free fatty acids oxidation and triglyceride clearance. There is a reported interruption of the metabolism of triglycerides in patients with bile acid diarrhoea (BAD) with a third of patients suffering with hypertriglyceridemia. Emerging treatments for BAD such as therapeutic imitation of the FXR may aid in alleviating symptoms and improving triglyceride levels.
Publish Date	2016-08-04 17:58
Citation	Sagar NM, McFarlane M, Nwokolo C, Bardhan KD, Arasaradnam RP. Mechanisms of triglyceride metabolism in patients with bile acid diarrhea. World J Gastroenterol 2016; 22(30): 6757-6763
URL	http://www.wjgnet.com/1007-9327/full/v22/i30/6757.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i30.6757

Full Article (PDF)	WJG-22-6757.pdf
Full Article (Word)	WJG-22-6757.doc
Manuscript File	25422-Review.doc
Answering Reviewers	25422-Answering reviewers.pdf
Audio Core Tip	25422-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	25422-Conflict-of-interest statement.pdf
Copyright License Agreement	25422-Copyright assignment.pdf
Peer-review Report	25422-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25422-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25422-Scientific misconduct check.pdf
Scientific Editor Work List	25422-Scientific editor work list.pdf