Publication Name	World Journal of Gastroenterology
Manuscript ID	2549
Country	China

Received	2013-02-28 15:44
Peer-Review Started	2013-03-01 09:50
To Make the First Decision	2013-03-25 15:24
Return for Revision	2013-04-01 13:45
Revised	2013-04-15 16:47
Second Decision	2013-05-09 13:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-10 10:48
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-02 10:43
Publish the Manuscript Online	2013-07-13 17:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Hugl-1 induces apoptosis in esophageal carcinoma cells both in vitro and in vivo
Manuscript Source	Invited Manuscript
All Author List	Jia Song, Xiu-Lan Peng, Meng-Yao Ji, Ming-Hua Ai, Ji-Xiang Zhang and Wei-Guo Dong
Funding Agency and Grant Number	Funding Agency Grant Number Fundamental Research Funds for the Central Universities 302274546
Corresponding Author	Dr. Wei-Guo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, Zhidong Zhang Road 99, Wuhan 430060, Hubei Province, China. dwg@whu.edu.cn
Key Words	Esophageal squamous cell carcinoma; Human giant larvae homolog 1; Proliferation; Apoptosis
Core Tip	In this paper, we constructed a plasmid to express Hugl-1 which has significant homology to the Drosophila tumor suppressor gene lethal giant larvae. The human esophageal squamous cell carcinoma cell line Eca109 was used as the object of study. We found a positive correlation between Hugl-1 expression and cell apoptosis in Eca109 cells both in vitro and in vivo. These data suggest that Hugl-1 is a tumor suppressor gene in esophageal cancer and may provide a novel target for the treatment of esophageal cancer patients.
Publish Date	2013-07-13 17:01
Citation	Song J, Peng XL, Ji MY, Ai MH, Zhang JX, Dong WG. Hugl-1 induces apoptosis in esophageal carcinoma cells both in vitro and in vivo. World J Gastroenterol 2013; 19(26): 4127-4136
URL	http://www.wjgnet.com/1007-9327/full/v19/i26/4127.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i26.4127

Full Article (PDF)	WJG-19-4127.pdf
Manuscript File	2549-Review.doc
Answering Reviewers	2549-Answering reviewers.pdf
Copyright License Agreement	2549-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2549-Language certificate.pdf
Peer-review Report	2549-Peer reviews.pdf
Scientific Editor Work List	2549-Scientific editor work list.doc