Publication Name	World Journal of Gastroenterology
Manuscript ID	25529
Country	China

Received	2016-03-13 12:17
Peer-Review Started	2016-03-13 12:23
To Make the First Decision	2016-03-31 10:09
Return for Revision	2016-03-31 16:12
Revised	2016-04-22 00:00
Second Decision	2016-04-26 12:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-05-04 17:45
Articles in Press	2016-05-04 17:45
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-05-16 20:37
Typeset the Manuscript	2016-05-25 11:39
Publish the Manuscript Online	2016-06-02 15:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Clinical significance of HOTAIR expression in colon cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Fen Luo, Dan Zhao, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu and Yun Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China U1504820
Corresponding Author	Yun Zhou, MD, Professor, Department of Oncology, Henan Provincial People’s Hospital, Weiwu Road No. 7, Zhengzhou 450003, Henan Province, China. luozhifen123@126.com
Key Words	HOTAIR; Long non-coding RNA; Oncogene; Colon tumor
Core Tip	This study aimed to detect the expression of HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer. Total RNA was extracted from 80 colon cancer tissues and matched tumor-adjacent normal colon tissues and reverse transcribed. HOTAIR expression was upregulated in colon cancer, suggesting that it may play an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR might acts as an oncogene and could be a new molecular target for the treatment of colon cancer.
Publish Date	2016-06-02 15:26
Citation	Luo ZF, Zhao D, Li XQ, Cui YX, Ma N, Lu CX, Liu MY, Zhou Y. Clinical significance of HOTAIR expression in colon cancer. World J Gastroenterol 2016; 22(22): 5254-5259
URL	http://www.wjgnet.com/1007-9327/full/v22/i22/5254.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i22.5254

Full Article (PDF)	WJG-22-5254.pdf
Full Article (Word)	WJG-22-5254.doc
Manuscript File	25529-Review.doc
Answering Reviewers	25529-Answering reviewers.pdf
Audio Core Tip	25529-Audio core tip.mp3
Biostatistics Review Certificate	25529-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25529-Conflict-of-interest statement.pdf
Copyright License Agreement	25529-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160313115909.doc
Institutional Review Board Approval Form or Document	25529-Institutional review board statement.pdf
Peer-review Report	25529-Peer-review(s).pdf
Scientific Misconduct Check	25529-Scientific misconduct check.pdf
Scientific Editor Work List	25529-Scientific editor work list.pdf