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Articles Published Processes
7/22/2016 1:36:00 PM | Browse: 1655 | Download: 2764
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Received |
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2016-03-14 10:03 |
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Peer-Review Started |
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2016-03-15 10:26 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-05-16 14:42 |
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Revised |
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2016-05-25 10:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-05-31 15:21 |
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Second Decision by Editor-in-Chief |
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2016-06-01 07:05 |
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Final Decision by Editorial Office Director |
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2016-06-13 17:49 |
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Articles in Press |
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2016-06-13 17:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-07-08 13:56 |
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Publish the Manuscript Online |
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2016-07-22 13:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Case Control Study |
| Article Title |
TCF7L2 rs7903146 polymorphism is associated with gastric cancer: A case-control study in the Venezuelan population
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Keila Torres, Luis Labrador, Elvis Valderrama and Miguel Angel Chiurillo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CDCHT-UCLA |
001-CS-2013 |
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| Corresponding Author |
Miguel Angel Chiurillo, MD, PhD, Departamento de Patologia Clínica, Universidade Estadual de Campinas, Campinas 13083, São Paulo, Brazil. mchiurillo@ucla.edu.ve |
| Key Words |
Gastric cancer; Wnt/β-catenin pathway; TCF7L2; Single nucleotide polymorphism; Genetic susceptibility |
| Core Tip |
TCF7L2 transcription factor plays an important role in transcriptional activation induced by the Wnt/β-catenin pathway, which is reported to be associated with human carcinogenesis and it is found activated in 30%-50% of gastric cancers. TCF7L2 polymorphisms rs12255372 and rs7903146 are associated with a significant risk of type 2 diabetes and in the development of several types of cancer. This is the first report of association of these TCF7L2 variants with the risk of gastric cancer. We conducted a case-control study including samples of Venezuelan patients in which the rs7903146 T allele was found associated with the risk of gastric cancer, suggesting its use as potential diagnosis biomarker in patients with this malignance. |
| Publish Date |
2016-07-22 13:48 |
| Citation |
Torres K, Labrador L, Valderrama E, Chiurillo MA. TCF7L2 rs7903146 polymorphism is associated with gastric cancer: A case-control study in the Venezuelan population. World J Gastroenterol 2016; 22(28): 6520-6526 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i28/6520.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i28.6520 |
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