Publication Name	World Journal of Gastroenterology
Manuscript ID	2557
Country	China

Received	2013-02-28 16:55
Peer-Review Started	2013-03-01 11:53
To Make the First Decision	2013-04-03 09:09
Return for Revision	2013-04-12 10:35
Revised	2013-04-22 10:20
Second Decision	2013-06-08 14:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-10 04:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-05 16:25
Publish the Manuscript Online	2013-07-13 17:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Effects of rhein on intestinal epithelial tight junction in IgA nephropathy
Manuscript Source	Unsolicited Manuscript
All Author List	Sheng-Nan Peng, Hui-Hong Zeng, Ai-Xiang Fu, Xiao-Wen Chen and Qing-Xian Zhu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81160050 Science and Technology Support Program of China 2008BAI68B01 Science and Technology Support Program of Jiangxi Province, China 20111BBG70015-3 Natural Science Foundation of Jiangxi Province 2007GQY0997
Corresponding Author	Qing-Xian Zhu, Professor, Department of Histology and Embryology, Medical College of Nanchang University, 461 Ba Yi Avenue, Nanchang 330006, Jiangxi Province, China. qxzzzz2008@163.com
Key Words	Intestine; Tight junction; Rhein; IgA nephropathy; Rat
Core Tip	It has been reported that the incidence and aggravation of IgA nephropathy (IgAN) are often accompanied with intestinal mucosal damage. We speculate that various factors cause the destruction of the intestinal mucosal barrier, food proteins activate the mucosal immune system, and a large amount of secretory IgA is deposited in kidney and causes IgAN. Rhubarb has a protective effect on the intestine. Rhein is isolated from rhubarb and we speculate that it also has a protective effect, although this has not been reported to date. We used various biochemical approaches to confirm this.
Publish Date	2013-07-13 17:01
Citation	Peng SN, Zeng HH, Fu AX, Chen XW, Zhu QX. Effects of rhein on intestinal epithelial tight junction in IgA nephropathy. World J Gastroenterol 2013; 19(26): 4137-4145
URL	http://www.wjgnet.com/1007-9327/full/v19/i26/4137.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i26.4137

Full Article (PDF)	WJG-19-4137.pdf
Manuscript File	2557-Review.doc
Answering Reviewers	2557-Answering reviewers.doc
Copyright License Agreement	2557-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2557-Language certificate.doc
Peer-review Report	2557-Peer review(s).pdf
Scientific Editor Work List	2557-Scientific editor work list.doc