Publication Name	World Journal of Gastroenterology
Manuscript ID	25573
Country	Egypt

Received	2016-03-15 09:50
Peer-Review Started	2016-03-18 09:16
To Make the First Decision	2016-05-12 09:14
Return for Revision	2016-05-16 14:59
Revised	2016-05-25 15:59
Second Decision	2016-05-31 15:21
Accepted by Journal Editor-in-Chief	2016-05-31 15:33
Accepted by Executive Editor-in-Chief	2016-06-13 17:45
Articles in Press	2016-06-13 17:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-30 19:42
Publish the Manuscript Online	2016-07-06 16:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Exploring the role of molecular biomarkers as a potential weapon against gastric cancer: A review of the literature
Manuscript Source	Invited Manuscript
All Author List	Marwa Matboli, Sarah El-Nakeep, Nourhan Hossam, Alaa Habieb, Ahmed EM Azazy, Ali E Ebrahim, Ziad Nagy and Omar Abdel-Rahman
Funding Agency and Grant Number
Corresponding Author	Dr. Omar Abdel-Rahman, Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Ain Shams University, Cairo 113331, Egypt. omar.abdelrhman@med.asu.edu.eg
Key Words	Gastric cancer; Molecular therapy; Targeted therapy; Biomarkers; Bioinformatics
Core Tip	We tried to highlight the role of molecular biomarkers as a predictor to chemotherapeutic response to existing regimens, aiming for better personalized therapy. Also we provided a summary of molecular markers that may aid in the development of rational therapeutic options for gastric cancer (GC) patients, aiming for improving their outcomes. However, among the plethora of agents targeting VEGF, EGFR, HER-2, IGF and mTOR pathways, trastuzumab and ramucirumab have been the only approved therapeutic options for use in advanced GC. Despite having many promising studies in their early stages, a lot have failed to prove their effectiveness in GC on the long run.
Publish Date	2016-07-06 16:53
Citation	Matboli M, El-Nakeep S, Hossam N, Habieb A, Azazy AEM, Ebrahim AE, Nagy Z, Abdel-Rahman O. Exploring the role of molecular biomarkers as a potential weapon against gastric cancer: A review of the literature. World J Gastroenterol 2016; 22(26): 5896-5908
URL	http://www.wjgnet.com/1007-9327/full/v22/i26/5896.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i26.5896

Full Article (PDF)	WJG-22-5896.pdf
Full Article (Word)	WJG-22-5896.doc
Manuscript File	25573-Review.docx
Answering Reviewers	25573-Answering reviewers.pdf
Audio Core Tip	25573-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25573-Conflict-of-interest statement.pdf
Copyright License Agreement	25573-Copyright assignment.pdf
Peer-review Report	25573-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25573-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25573-Scientific misconduct check.pdf
Scientific Editor Work List	25573-Scientific editor work list.pdf