Publication Name	World Journal of Immunology
Manuscript ID	25576
Country	United States

Received	2016-03-15 09:32
Peer-Review Started	2016-03-17 17:04
To Make the First Decision	2016-04-15 08:20
Return for Revision	2016-04-18 18:17
Revised	2016-04-26 03:23
Second Decision	2016-06-12 10:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-29 10:08
Articles in Press	2016-06-29 10:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-18 10:29
Publish the Manuscript Online	2016-07-20 15:35

ISSN	2219-2824 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Basic Study
Article Title	Regulatory T cells suppress autoreactive CD4+ T cell response to bladder epithelial antigen
Manuscript Source	Invited Manuscript
All Author List	Wu-Jiang Liu and Yi Luo
Funding Agency and Grant Number	Funding Agency Grant Number The National Institutes of Health to Y.L RO1DK066079
Corresponding Author	Yi Luo, MD, PhD, Associate Professor of Urology, Department of Urology, University of Iowa Carver College of Medicine, 3204 MERF, 375 Newton Road, Iowa City, IA 52242-1087, United States. yi-luo@uiowa.edu
Key Words	Bladder; Autoimmunity; Regulatory T cell; CD4+ T cells; Antigen
Core Tip	Evidence suggests that autoimmune inflam-mation may cause interstitial cystitis/bladder pain syndrome (IC/BPS) in subgroups of patients. However, the role of regulatory T (Treg) cells in the control of bladder autoimmunity has not yet been identified. In this study we developed novel transgenic autoimmune cystitis models and demonstrated that Treg cells specific for bladder epithelial Ag play an important role in immunological homeostasis and the control of CD4+ T cell-mediated bladder autoimmune inflammation. Our results suggest that loss of functional Treg cells may contribute to IC/BPS pathology in subgroups of patients.
Publish Date	2016-07-20 15:35
Citation	Liu WJ, Luo Y. Regulatory T cells suppress autoreactive CD4+ T cell response to bladder epithelial antigen. World J Immunol 2016; 6(2): 105-118
URL	http://www.wjgnet.com/2219-2824/full/v6/i2/105.htm
DOI	http://dx.doi.org/10.5411/wji.v6.i2.105

Full Article (PDF)	WJI-6-105.pdf
Full Article (Word)	WJI-6-105.doc
Manuscript File	25576-Review.docx
Answering Reviewers	25576-Answering reviewers.pdf
Audio Core Tip	25576-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25576-Conflict-of-interest statement.pdf
Copyright License Agreement	25576-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25576-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	25576-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	25576-Language certificate.pdf
Peer-review Report	25576-Peer-review(s).pdf
Scientific Misconduct Check	25576-Scientific misconduct check.pdf
Scientific Editor Work List	25576-Scientific editor work list.pdf