Publication Name	World Journal of Gastroenterology
Manuscript ID	25582
Country	China

Received	2016-03-15 17:22
Peer-Review Started	2016-03-18 10:04
To Make the First Decision	2016-05-12 09:16
Return for Revision	2016-05-17 09:11
Revised	2016-05-24 11:50
Second Decision	2016-05-31 15:21
Accepted by Journal Editor-in-Chief	2016-06-01 12:42
Accepted by Executive Editor-in-Chief	2016-06-13 17:46
Articles in Press	2016-06-13 17:46
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-06-19 04:14
Typeset the Manuscript	2016-08-03 13:46
Publish the Manuscript Online	2016-08-04 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Mechanisms of drug resistance in colon cancer and its therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Tao Hu, Zhen Li, Chun-Ying Gao and Chi Hin Cho
Funding Agency and Grant Number
Corresponding Author	Tao Hu, PhD, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. taohu1985@hotmail.com
Key Words	Colon cancer; Drug resistance; ATP-binding cassette transporters; Evasion of apoptosis; Autophagy
Core Tip	Drug resistance in colon cancer is still an obstacle to successful chemotherapy. This review focuses on over-expression of ATP-binding cassette transporters and evasion of apoptosis, two representatives of transport-based and non-transport-based mechanisms of drug resistance, as well as their therapeutic strategies. Given that the drug resistance mechanisms are different among colon cancer patients and may change even in a single patient at different stages, personalized and specific combination therapy is proposed to be more effective and safer for the reversal of drug resistance in the clinical setting.
Publish Date	2016-08-04 17:58
Citation	Hu T, Li Z, Gao CY, Cho CH. Mechanisms of drug resistance in colon cancer and its therapeutic strategies. World J Gastroenterol 2016; 22(30): 6876-6889
URL	http://www.wjgnet.com/1007-9327/full/v22/i30/6876.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i30.6876

Full Article (PDF)	WJG-22-6876.pdf
Full Article (Word)	WJG-22-6876.doc
Manuscript File	25582-Review.docx
Answering Reviewers	25582-Answering reviewers.pdf
Audio Core Tip	25582-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	25582-Conflict-of-interest statement.pdf
Copyright License Agreement	25582-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25582-Language certificate.pdf
Peer-review Report	25582-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25582-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25582-Scientific misconduct check.pdf
Scientific Editor Work List	25582-Scientific editor work list.pdf