Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	25596
Country	India

Received	2016-03-16 08:57
Peer-Review Started	2016-03-18 10:24
First Decision by Editorial Office Director
Return for Revision	2016-05-19 10:29
Revised	2016-06-27 00:00
Publication Fee Transferred
Second Decision by Editor	2016-08-08 15:21
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-08-16 14:01
Articles in Press	2016-08-16 14:01
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-27 12:08
Publish the Manuscript Online	2016-11-07 10:11

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Systematic Reviews
Article Title	Zinc supplementation as an adjunct to standard therapy in childhood nephrotic syndrome - a systematic review
Manuscript Source	Invited Manuscript
All Author List	Girish Chandra Bhatt, Shikha Jain and Rashmi Ranjan Das
Funding Agency and Grant Number
Corresponding Author	Rashmi Ranjan Das, MD, Department of Pediatrics, All India Institute of Medical Sciences, SIJUA, Bhubaneswar 751019, India. rrdas05@gmail.com
Key Words	Nephrotic syndrome; Pediatric; Relapse; Zinc; Micronutrient
Core Tip	Relapses in nephrotic syndrome (NS) increase morbidity and mortality. Studies have shown that zinc deficiency is common in NS. Zinc defi-ciency might lead to down-regulation of T-helper 1 (Th1) cytokines, a relative T-helper 2 (Th2) bias, and an increased risk of infection. The later commonly associated with relapse in NS. Zinc supplementation restores Th1-Th2 im-balance and may decrease relapse. The primary aim of this review is to evaluate the efficacy of zinc in preventing relapses in childhood NS (steroid sensitive and steroid dependent/frequent relapsing). The secondary aim is to evaluate the safety of zinc supplementation in this regard.
Publish Date	2016-11-07 10:11
Citation	Bhatt GC, Jain S, Das RR. Zinc supplementation as an adjunct to standard therapy in childhood nephrotic syndrome - a systematic review. World J Clin Pediatr 2016; 5(4): 383-390
URL	http://www.wjgnet.com/2219-2808/full/v5/i4/383.htm
DOI	http://dx.doi.org/10.5409/wjcp.v5.i4.383

Full Article (PDF)	WJCP-5-383.pdf
Full Article (Word)	WJCP-5-383.doc
Manuscript File	25596-Review.doc
Answering Reviewers	25596-Answering reviewers.pdf
Audio Core Tip	25596-Audio core tip.mp3
Biostatistics Review Certificate	Biostatistics_Statement_20160316015952.doc
Clinical Trial Registration Statement	DeclarationOf_HelsinkiConformation_Statement_20160316015735.doc
Conflict-of-Interest Disclosure Form	25596-Conflict-of-interest statement.pdf
Copyright License Agreement	25596-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25596-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160316014758.jpg
Peer-review Report	25596-Peer-review(s).pdf
Scientific Misconduct Check	25596-Scientific misconduct check.pdf
Scientific Editor Work List	25596-Scientific editor work list.pdf