Publication Name	World Journal of Gastroenterology
Manuscript ID	25619
Country	Japan

Received	2016-03-17 10:15
Peer-Review Started	2016-03-20 12:39
To Make the First Decision	2016-04-14 11:14
Return for Revision	2016-04-17 17:00
Revised	2016-04-22 10:44
Second Decision	2016-05-06 17:36
Accepted by Journal Editor-in-Chief	2016-05-06 17:56
Accepted by Executive Editor-in-Chief	2016-05-23 16:21
Articles in Press	2016-05-23 16:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-27 08:48
Publish the Manuscript Online	2016-06-13 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Fibroblasts, an inconspicuous but essential player in colon cancer development and progression
Manuscript Source	Invited Manuscript
All Author List	Naofumi Mukaida and Soichiro Sasaki
Funding Agency and Grant Number	Funding Agency Grant Number CREST from AMED and Japan Society for the Promotion of Science
Corresponding Author	Naofumi Mukaida, MD, PhD, Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. mukaida@staff.kanazawa-u.ac.jp
Key Words	Angiogenesis; Drug resistance; Extracellular matrix; Immune evasion; Transforming growth factor-β; Invasion; Metastasis
Core Tip	Tumor microenvironments have a crucial role in cancer initiation and progression, and consist of various types of cells, such as endothelial cells, leukocytes, and fibroblasts. Compared with endothelial cells and leukocytes, less attention has been paid to the roles of cancer-associated fibroblasts (CAFs), fibroblasts present in tumor tissues, because their heteroge-neity hinders the elucidation on them at cellular and molecular levels. Here, we will discuss the origin of CAFs and their crucial roles in cancer initiation and progression, and the possibility to develop a novel type of anti-cancer treatment by manipulating the migration and functions of CAFs.
Publish Date	2016-06-13 09:14
Citation	Mukaida N, Sasaki S. Fibroblasts, an inconspicuous but essential player in colon cancer development and progression. World J Gastroenterol 2016; 22(23): 5301-5316
URL	http://www.wjgnet.com/1007-9327/full/v22/i23/5301.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i23.5301

Full Article (PDF)	WJG-22-5301.pdf
Full Article (Word)	WJG-22-5301.doc
Manuscript File	25619-Review.docx
Answering Reviewers	25619-Answering reviewers.pdf
Audio Core Tip	25619-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25619-Conflict-of-interest statement.pdf
Copyright License Agreement	25619-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25619-Language certificate.pdf
Peer-review Report	25619-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25619-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25619-Scientific misconduct check.pdf
Scientific Editor Work List	25619-Scientific editor work list.pdf