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9/1/2016 9:16:00 AM | Browse: 417 | Download: 511
Publication Name World Journal of Nephrology
Manuscript ID 25629
Country/Territory Egypt
Received
2016-03-17 09:43
Peer-Review Started
2016-03-19 15:24
To Make the First Decision
2016-04-15 08:22
Return for Revision
2016-04-19 16:42
Revised
2016-04-20 07:08
Second Decision
2016-06-12 10:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-06-29 10:12
Articles in Press
2016-06-29 10:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-08-26 15:38
Publish the Manuscript Online
2016-09-01 09:16
ISSN 2220-6124 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Urology and Nephrology
Manuscript Type Review
Article Title Vascular calcification: When should we interfere in chronic kidney disease patients and how?
Manuscript Source Invited Manuscript
All Author List Usama Abdel Azim Sharaf El Din, Mona Mansour Salem and Dina Ossama Abdulazim
Funding Agency and Grant Number
Corresponding author Usama Abdel Azim Sharaf El Din, MD, Professor, Department of Nephrology, School of Medicine, Cairo University, 58th Abbas El Akkad St., Nasr City, Cairo 11759, Egypt. usamaaas@gmail.com
Keywords Chronic kidney disease; Uremia; Calcification; Sevelamer; Calcific uremic arteriolopathy; Fibroblast growth factor 23; Klotho; Phosphate binders; Kidney transplantation
Core Tip The last 2 decades witnessed the failure of all intervention studies targeting different risk factors of vascular calcification in chronic kidney disease (CKD) patients on regular hemodialysis. The main aim of all these studies was to decrease cardiovascular morbidity and mortality among such patients. These disappointing results criticized the value of such interventions in clinical practice. On the other hand, when similar trials were run on patients at an earlier stage of CKD, most of these trials showed a significant impact on patient survival and/or cardiovascular morbidity. Such discrepancy indicates the value of timing of interference. We are trying in this review to develop the ideal strategy that would optimize the management of CKD patients to avoid the devastating vascular calcification, highlighting the value of different medicines used in this plan. Meanwhile we are showing the update in guidelines concerned with this issue.
Publish Date 2016-09-01 09:16
Citation Sharaf El Din UAA, Salem MM, Abdulazim DO. Vascular calcification: When should we interfere in chronic kidney disease patients and how? World J Nephrol 2016; 5(5): 398-417
Url http://www.wjgnet.com/2220-6124/full/v5/i5/398.htm
DOI http://dx.doi.org/10.5527/wjn.v5.i5.398
Full Article (PDF) WJN-5-398.pdf
Full Article (Word) WJN-5-398.doc
Manuscript File 25629-Review.docx
Answering Reviewers 25629-Answering reviewers.pdf
Audio Core Tip 25629-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 25629-Conflict-of-interest statement.pdf
Copyright License Agreement 25629-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 25629-Language certificate.pdf
Peer-review Report 25629-Peer-review(s).pdf
Scientific Misconduct Check 25629-Scientific misconduct check.pdf
Scientific Editor Work List 25629-Scientific editor work list.pdf