Publication Name	World Journal of Nephrology
Manuscript ID	25629
Country	Egypt

Received	2016-03-17 09:43
Peer-Review Started	2016-03-19 15:24
To Make the First Decision	2016-04-15 08:22
Return for Revision	2016-04-19 16:42
Revised	2016-04-20 07:08
Second Decision	2016-06-12 10:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-29 10:12
Articles in Press	2016-06-29 10:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-26 15:38
Publish the Manuscript Online	2016-09-01 09:16

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Vascular calcification: When should we interfere in chronic kidney disease patients and how?
Manuscript Source	Invited Manuscript
All Author List	Usama Abdel Azim Sharaf El Din, Mona Mansour Salem and Dina Ossama Abdulazim
Funding Agency and Grant Number
Corresponding Author	Usama Abdel Azim Sharaf El Din, MD, Professor, Department of Nephrology, School of Medicine, Cairo University, 58th Abbas El Akkad St., Nasr City, Cairo 11759, Egypt. usamaaas@gmail.com
Key Words	Chronic kidney disease; Uremia; Calcification; Sevelamer; Calcific uremic arteriolopathy; Fibroblast growth factor 23; Klotho; Phosphate binders; Kidney transplantation
Core Tip	The last 2 decades witnessed the failure of all intervention studies targeting different risk factors of vascular calcification in chronic kidney disease (CKD) patients on regular hemodialysis. The main aim of all these studies was to decrease cardiovascular morbidity and mortality among such patients. These disappointing results criticized the value of such interventions in clinical practice. On the other hand, when similar trials were run on patients at an earlier stage of CKD, most of these trials showed a significant impact on patient survival and/or cardiovascular morbidity. Such discrepancy indicates the value of timing of interference. We are trying in this review to develop the ideal strategy that would optimize the management of CKD patients to avoid the devastating vascular calcification, highlighting the value of different medicines used in this plan. Meanwhile we are showing the update in guidelines concerned with this issue.
Publish Date	2016-09-01 09:16
Citation	Sharaf El Din UAA, Salem MM, Abdulazim DO. Vascular calcification: When should we interfere in chronic kidney disease patients and how? World J Nephrol 2016; 5(5): 398-417
URL	http://www.wjgnet.com/2220-6124/full/v5/i5/398.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i5.398

Full Article (PDF)	WJN-5-398.pdf
Full Article (Word)	WJN-5-398.doc
Manuscript File	25629-Review.docx
Answering Reviewers	25629-Answering reviewers.pdf
Audio Core Tip	25629-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25629-Conflict-of-interest statement.pdf
Copyright License Agreement	25629-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25629-Language certificate.pdf
Peer-review Report	25629-Peer-review(s).pdf
Scientific Misconduct Check	25629-Scientific misconduct check.pdf
Scientific Editor Work List	25629-Scientific editor work list.pdf