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9/8/2016 10:53:00 AM | Browse: 82 | Download: 122
Publication Name World Journal of Gastroenterology
Manuscript ID 25665
Country of Manuscript Source Italy
Received
2016-03-18 08:38
Peer-Review Started
2016-03-21 16:41
To Make the First Decision
2016-04-14 11:14
Return for Revision
2016-04-17 17:36
Revised
Second Decision
2016-08-01 19:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-08 17:32
Articles in Press
2016-08-08 17:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-08-26 09:56
Publish the Manuscript Online
2016-09-08 10:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Review
Article Title Challenges of advanced hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Stefano Colagrande, Andrea L Inghilesi, Sami Aburas, Gian G Taliani, Cosimo Nardi and Fabio Marra
Funding Agency and Grant Number
Correspondence To Stefano Colagrande, MD, Dipartimento di Scienze Biomediche, Sperimentali e Cliniche, Largo Brambilla 3, I-50134 Florence, Italy. stefano.colagrande@unifi.it
Keywords Barcelona Clinic Liver Cancer; Portal vein thrombosis; Modified Response Evaluation Criteria in Solid Tumors; Advanced hepatocellular carcinoma management; Advanced hepatocellular carcinoma second line therapies; Sorafenib
Core Tip Hepatocellular carcinoma (HCC) is an aggressive malignancy, which accounts for great part of all cancer deaths each year. Its management is complex, and although the surveillance performed, many patients have an advanced stage. This comprehends an heterogeneous groups with different clinical condition; sorafenib is the only approved treatment, however affected by many adverse events. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Loco-regional therapies as TAE/TACE and TARE have also been tested and at now are under evaluation. This review will focus on patients with advanced HCC and highlights potential and limit of the therapies.
Publish Date 2016-09-08 10:53
Citation Colagrande S, Inghilesi AL, Aburas S, Taliani GG, Nardi C, Marra F. Challenges of advanced hepatocellular carcinoma. World J Gastroenterol 2016; 22(34): 7645-7659
Url http://www.wjgnet.com/1007-9327/full/v22/i34/7645.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i34.7645
Full Article (PDF) WJG-22-7645.pdf
Full Article (Word) WJG-22-7645.doc
Revised Manuscript 25665-Review.docx
Peer-review Report 25665-Peer-review(s).pdf
Answering Reviewers 25665-Answering reviewers.pdf
Scientific Misconduct Check 25665-Scientific misconduct check.pdf
Scientific Editor Work List 25665-Scientific editor work list.pdf
Audio Core Tip 25665-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 25665-Conflict-of-interest statement.pdf
Copyright License Agreement 25665-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 25665-Language certificate.pdf