Publication Name	World Journal of Gastroenterology
Manuscript ID	25701
Country	Germany

Received	2016-03-21 09:30
Peer-Review Started	2016-03-22 17:13
To Make the First Decision	2016-05-30 08:34
Return for Revision	2016-05-30 18:44
Revised	2016-06-03 16:42
Second Decision	2016-06-21 10:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-28 15:07
Articles in Press	2016-06-28 15:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-30 10:56
Publish the Manuscript Online	2016-07-06 16:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Pancreatic cancer stem cell markers and exosomes - the incentive push
Manuscript Source	Invited Manuscript
All Author List	Sarah Heiler, Zhe Wang and Margot Zöller
Funding Agency and Grant Number	Funding Agency Grant Number Wilhelm Sander Stiftung 2009.100.2 to Zöller M German Cancer Research Aid 110836 to Zöller M China Scholarship Council CSC 201408080067 to Wang Z
Corresponding Author	Dr. Margot Zöller, Tumor Cell Biology, University Hospital of Surgery, Im Neuenheimer Feld 365, D 69120 Heidelberg, Germany. m.zoeller@uni-hd.de
Key Words	Pancreatic cancer; Cancer stem cells; Stem cell markers; Exosomes; Crosstalk
Core Tip	Cancer progression relies on a small population of cancer stem cells (CSC), characterized by longevity, self renewal, drug resistance and requirement of a niche. In addition, CSC abundantly deliver exosomes (TEX) allowing CSC a long distance communication. At the descriptive level, CSC are characterized by a set of so called CSC markers. We here discuss for pancreatic cancer that the CSC markers CD44v6, c-Met, Tspan8, alpha6beta4, EpCAM, claudin7, CXCR4 and prominin1 can in a concerted activity account for all CSC features. This includes CSC TEX activity due to the engagement of CSC markers in TEX biogenesis and enrichment in TEX.
Publish Date	2016-07-06 16:53
Citation	Heiler S, Wang Z, Zöller M. Pancreatic cancer stem cell markers and exosomes - the incentive push. World J Gastroenterol 2016; 22(26): 5971-6007
URL	http://www.wjgnet.com/1007-9327/full/v22/i26/5971.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i26.5971

Full Article (PDF)	WJG-22-5971.pdf
Full Article (Word)	WJG-22-5971.doc
Manuscript File	25701-Review.doc
Answering Reviewers	25701-Answering reviewers.pdf
Audio Core Tip	25701-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25701-Conflict-of-interest statement.pdf
Copyright License Agreement	25701-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25701-Grant application form(s).pdf
Supplementary Material	Supplementary_Material_20160319055853.pdf
Peer-review Report	25701-Peer-review(s).pdf
Scientific Misconduct Check	25701-Scientific misconduct check.pdf
Scientific Editor Work List	25701-Scientific editor work list.pdf