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Articles Published Processes
7/6/2016 4:53:00 PM | Browse: 1536 | Download: 2916
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Received |
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2016-03-21 09:30 |
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Peer-Review Started |
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2016-03-22 17:13 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-05-30 18:44 |
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Revised |
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2016-06-03 16:42 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-06-21 10:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2016-06-28 15:07 |
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Articles in Press |
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2016-06-28 15:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-06-30 10:56 |
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Publish the Manuscript Online |
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2016-07-06 16:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Pancreatic cancer stem cell markers and exosomes - the incentive push
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sarah Heiler, Zhe Wang and Margot Zöller |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wilhelm Sander Stiftung |
2009.100.2 to Zöller M |
| German Cancer Research Aid |
110836 to Zöller M |
| China Scholarship Council |
CSC 201408080067 to Wang Z |
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| Corresponding Author |
Dr. Margot Zöller, Tumor Cell Biology, University Hospital of Surgery, Im Neuenheimer Feld 365, D 69120 Heidelberg, Germany. m.zoeller@uni-hd.de |
| Key Words |
Pancreatic cancer; Cancer stem cells; Stem cell markers; Exosomes; Crosstalk |
| Core Tip |
Cancer progression relies on a small population of cancer stem cells (CSC), characterized by longevity, self renewal, drug resistance and requirement of a niche. In addition, CSC abundantly deliver exosomes (TEX) allowing CSC a long distance communication. At the descriptive level, CSC are characterized by a set of so called CSC markers. We here discuss for pancreatic cancer that the CSC markers CD44v6, c-Met, Tspan8, alpha6beta4, EpCAM, claudin7, CXCR4 and prominin1 can in a concerted activity account for all CSC features. This includes CSC TEX activity due to the engagement of CSC markers in TEX biogenesis and enrichment in TEX. |
| Publish Date |
2016-07-06 16:53 |
| Citation |
Heiler S, Wang Z, Zöller M. Pancreatic cancer stem cell markers and exosomes - the incentive push. World J Gastroenterol 2016; 22(26): 5971-6007 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i26/5971.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i26.5971 |
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