Publication Name	World Journal of Gastroenterology
Manuscript ID	25724
Country	United States

Received	2016-03-20 16:28
Peer-Review Started	2016-03-22 18:58
To Make the First Decision	2016-05-12 09:14
Return for Revision	2016-05-16 16:19
Revised	2016-05-20 07:14
Second Decision	2016-05-31 15:22
Accepted by Journal Editor-in-Chief	2016-06-01 12:40
Accepted by Executive Editor-in-Chief	2016-06-13 17:50
Articles in Press	2016-06-13 17:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-27 08:44
Publish the Manuscript Online	2016-07-04 14:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Genomic diversity of colorectal cancer: Changing landscape and emerging targets
Manuscript Source	Invited Manuscript
All Author List	Daniel H Ahn, Kristen K Ciombor, Sameh Mikhail and Tanios Bekaii-Saab
Funding Agency and Grant Number
Corresponding Author	Tanios Bekaii-Saab, MD, Division of Medical Oncology, Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ 85054, United States. bekaii-saab.tanios@mayo.edu
Key Words	Colorectal cancer; KRAS mutation; BRAF mutation; Genomic diversity; Tumor DNA
Core Tip	Tumor somatic variants have a prognostic role, in addition to treatment selection in patients with solid tumor malignancies, including colorectal cancer (CRC). The application of this knowledge in the development of novel, targeted therapies has resulted in improved patient outcomes in this disease. Our objective is to provide an overview of the genomic alterations present in CRC and its role in treatment implications, in addition to providing an overview of ongoing and future clinical trials.
Publish Date	2016-07-04 14:42
Citation	Ahn DH, Ciombor KK, Mikhail S, Bekaii-Saab T. genomic diversity of colorectal cancer: Changing landscape and emerging targets. World J Gastroenterol 2016; 22(25): 5668-5677
URL	http://www.wjgnet.com/1007-9327/full/v22/i25/5668.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i25.5668

Full Article (PDF)	WJG-22-5668.pdf
Full Article (Word)	WJG-22-5668.doc
Manuscript File	25724-Review.docx
Answering Reviewers	25724-Answering reviewers.pdf
Audio Core Tip	25724-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25724-Conflict-of-interest statement.pdf
Copyright License Agreement	25724-Copyright assignment.pdf
Peer-review Report	25724-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25724-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25724-Scientific misconduct check.pdf
Scientific Editor Work List	25724-Scientific editor work list.pdf