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12/15/2016 4:06:00 PM | Browse: 778 | Download: 1070
Publication Name World Journal of Hepatology
Manuscript ID 25785
Country/Territory Germany
Received
2016-03-23 10:03
Peer-Review Started
2016-03-23 11:20
To Make the First Decision
2016-07-04 16:49
Return for Revision
2016-07-05 09:51
Revised
2016-07-15 16:51
Second Decision
2016-09-05 09:43
Accepted by Journal Editor-in-Chief
2016-09-06 19:00
Accepted by Company Editor-in-Chief
2016-09-18 14:15
Articles in Press
2016-09-18 14:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-07 18:12
Publish the Manuscript Online
2016-12-15 16:07
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the <i>PNPLA3</i> variant I148M
Manuscript Source Unsolicited Manuscript
All Author List Vanessa Rausch, Teresa Peccerella, Carolin Lackner, Eray Yagmur, Helmut-Karl Seitz, Thomas Longerich and Sebastian Mueller
Funding Agency and Grant Number
Funding Agency Grant Number
German Research Foundation DFG, RA-2677/1-1
Dietmar Hopp-Foundation 2301196
Corresponding Author Sebastian Mueller, MD, PhD, Salem Medical Center and Center for Alcohol Research, University of Heidelberg, Zeppelinstraße 11-33, 69120 Heidelberg, Germany. sebastian.mueller@urz.uni-heidelberg.de
Key Words Liver stiffness; Alcoholic liver disease; Adiponutrin; <i>PNPLA3</i>; Transient elastography; Alcohol withdrawal; Inflammation
Core Tip The role of the <i>PNPLA3</i> rs738409 variant (CG and GG) on histology and liver stiffness in response to alcohol detoxification was studied in a large monocentric cohort of heavy drinkers with various stages of ALD. About 20% of our patients with alcoholic liver cirrhosis were attributable to <i>PNPLA3</i> G variants with an OR to develop cirrhosis of 1.295. Our data further show that <i>PNPLA3</i> GG carriers primarily develop ballooning and not steatosis causing a delayed resolution of liver stiffness after alcohol withdrawal. We suggest that the delayed ballooning-associated stiffness elevation may contribute to fibrosis progression (see also the sinusoidal pressure hypothesis).
Publish Date 2016-12-15 16:07
Citation Rausch V, Peccerella T, Lackner C, Yagmur E, Seitz HK, Longerich T, Mueller S. Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the PNPLA3 variant I148M. World J Hepatol 2016; 8(35): 1547-1556
URL http://www.wjgnet.com/1948-5182/full/v8/i35/1547.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i35.1547
Full Article (PDF) WJH-8-1547.pdf
Full Article (Word) WJH-8-1547.doc
Manuscript File 25785-Review.docx
Answering Reviewers 25785-Answering reviewers.pdf
Audio Core Tip 25785-Audio core tip.wav
Biostatistics Review Certificate 25785-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 25785-Conflict-of-interest statement.pdf
Copyright License Agreement 25785-Copyright assignment.pdf
Data Sharing Statement 25785-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 25785-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160322175503.docx
Institutional Review Board Approval Form or Document 25785-Institutional review board statement.pdf
Scientific Research Process 25785-Scientific research process.pdf
Supplementary Material 25785-Supplementary material.pdf
Peer-review Report 25785-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 25785-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 25785-Scientific misconduct check.pdf
Scientific Editor Work List 25785-Scientific editor work list.pdf