Publication Name	World Journal of Stem Cells
Manuscript ID	25786
Country	India

Received	2016-03-23 10:01
Peer-Review Started	2016-03-23 16:41
To Make the First Decision	2016-04-15 08:53
Return for Revision	2016-04-15 11:32
Revised	2016-04-29 18:21
Second Decision	2016-05-16 08:44
Accepted by Journal Editor-in-Chief	2016-05-16 12:36
Accepted by Executive Editor-in-Chief	2016-06-02 16:03
Articles in Press	2016-06-02 16:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-06-28 09:03
Typeset the Manuscript	2016-07-08 16:29
Publish the Manuscript Online	2016-07-19 08:19

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Clinical Trials Study
Article Title	Therapeutic potential of human embryonic stem cells in type 2 diabetes mellitus
Manuscript Source	Unsolicited Manuscript
All Author List	Geeta Shroff
Funding Agency and Grant Number
Corresponding Author	Dr. Geeta Shroff, Director, Nutech Mediworld, H-8, Green Park Extension, New Delhi 110016, India. geetashroff@hotmail.com
Key Words	Type 2 diabetes mellitus; Human embryonic stem cells; Insulin; Glycated hemoglobin; Nutech functional scoring scale
Core Tip	We began research on human embryonic stem cell (hESC) therapy in 1999. Today, we have used it in > 1400 patients, and have got patent for our technology in 65 countries including the United States. This study focused on the safety and efficacy of hESCs in patients who were chronically affected with type 2 diabetes mellitus (T2DM). Patients with a previous history of diabetes and its associated complications were enrolled and injected with hESC lines as per the defined protocol. The patients were assessed using Nutech functional score (NFS) (another invention of Nutech Mediworld), a numeric scoring scale to evaluate the patients for 11 diagnostic parameters. All the parameters were graded on the NFS scale from 1 to 5. Highest possible grade (HPG) of 5 was considered as the grade of best improvement. Patients were evaluated at baseline and at the end of treatment period 1 (T1). Overall, 94.8% of the patients showed improvement by at least one grade of NFS at the end of T1. For all the 11 parameters evaluated, 54% of patients achieved HPG after treatment. Important parameters like glycated hemoglobin, insulin and use of oral hypoglycemic drugs with and without use of insulin were measured and their results have been presented in detail. It has been concluded from the study that hESC therapy is beneficial in patients with diabetes and helps in reducing their dependence on insulin and other conventional medicines. Their remarkable properties of reducing risk of immune mediated rejections and absence of hypoglycemic episodes while treating T2DM patients favor their use in management of T2DM.
Publish Date	2016-07-19 08:19
Citation	Shroff G. Therapeutic potential of human embryonic stem cells in type 2 diabetes mellitus. World J Stem Cells 2016; 8(7): 223-230
URL	http://www.wjgnet.com/1948-0210/full/v8/i7/223.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i7.223

Full Article (PDF)	WJSC-8-223.pdf
Full Article (Word)	WJSC-8-223.doc
Manuscript File	25786-Review.docx
Answering Reviewers	25786-Answering reviewers.pdf
Audio Core Tip	25786-Audio core tip.mp3
Biostatistics Review Certificate	25786-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25786-Conflict-of-interest statement.pdf
Copyright License Agreement	25786-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160322182605.pdf
Institutional Review Board Approval Form or Document	25786-Institutional review board statement.pdf
Peer-review Report	25786-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25786-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25786-Scientific misconduct check.pdf
Scientific Editor Work List	25786-Scientific editor work list.pdf