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Articles Published Processes
7/22/2016 1:36:00 PM | Browse: 794 | Download: 998
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Received |
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2016-03-24 09:49 |
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Peer-Review Started |
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2016-03-24 16:02 |
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To Make the First Decision |
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2016-05-12 14:37 |
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Return for Revision |
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2016-05-12 15:38 |
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Revised |
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2016-05-21 05:27 |
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Second Decision |
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2016-06-06 08:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-06-15 18:49 |
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Articles in Press |
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2016-06-15 18:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-07-11 15:31 |
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Publish the Manuscript Online |
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2016-07-22 13:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Specific CD8+ T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Elia Moreno-Cubero and Juan-Ramón Larrubia |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| “Instituto de Salud Carlos III”, Spain & “European Regional Development Fund (ERDF), a way of making Europe” |
PI12/00130 |
| “Instituto de Salud Carlos III”, Spain & “European Regional Development Fund (ERDF), a way of making Europe” |
PI15/00074 |
| “Gilead Spain & Instituto de Salud Carlos III” |
GLD14_00217 |
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| Corresponding Author |
Juan-Ramón Larrubia, MD, MSc, PhD, Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, E-19002 Guadalajara, Spain. juan.larrubia@uah.es |
| Key Words |
Hepatocellular carcinoma; CD8+ T cells; Immune checkpoint modulation; Chronic viral hepatitis; Cytotoxic T-lymphocyte antigen-4; Programmed cell death protein-1 |
| Core Tip |
In certain types of chronic diseases, such as hepatocellular carcinoma and chronic viral hepatitis, disease curation involves restoration of the specific cytotoxic T cell response. Chronic hepatotropic viruses and tumoural cells develop mechanisms to induce exhaustion of the specific CD8+ T cells in order to escape immune destruction. One hallmark of this dysfunction is the overexpression of negative co-stimulatory molecules. Blockade of these negative co-stimulatory pathways, a process known as immune checkpoint modulation, is a promising novel therapy that could improve the treatment of liver diseases that feature T cell exhaustion. |
| Publish Date |
2016-07-22 13:48 |
| Citation |
Moreno-Cubero E, Larrubia JR. Specific CD8+ T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis. World J Gastroenterol 2016; 22(28): 6469-6483 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i28/6469.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i28.6469 |
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