Publication Name	World Journal of Gastroenterology
Manuscript ID	25829
Country	Spain

Received	2016-03-24 09:49
Peer-Review Started	2016-03-24 16:02
First Decision by Editorial Office Director
Return for Revision	2016-05-12 15:38
Revised	2016-05-21 05:27
Publication Fee Transferred
Second Decision by Editor	2016-06-06 08:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-06-15 18:49
Articles in Press	2016-06-15 18:49
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-11 15:31
Publish the Manuscript Online	2016-07-22 13:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Specific CD8+ T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis
Manuscript Source	Invited Manuscript
All Author List	Elia Moreno-Cubero and Juan-Ramón Larrubia
Funding Agency and Grant Number	Funding Agency Grant Number “Instituto de Salud Carlos III”, Spain & “European Regional Development Fund (ERDF), a way of making Europe” PI12/00130 “Instituto de Salud Carlos III”, Spain & “European Regional Development Fund (ERDF), a way of making Europe” PI15/00074 “Gilead Spain & Instituto de Salud Carlos III” GLD14_00217
Corresponding Author	Juan-Ramón Larrubia, MD, MSc, PhD, Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, E-19002 Guadalajara, Spain. juan.larrubia@uah.es
Key Words	Hepatocellular carcinoma; CD8+ T cells; Immune checkpoint modulation; Chronic viral hepatitis; Cytotoxic T-lymphocyte antigen-4; Programmed cell death protein-1
Core Tip	In certain types of chronic diseases, such as hepatocellular carcinoma and chronic viral hepatitis, disease curation involves restoration of the specific cytotoxic T cell response. Chronic hepatotropic viruses and tumoural cells develop mechanisms to induce exhaustion of the specific CD8+ T cells in order to escape immune destruction. One hallmark of this dysfunction is the overexpression of negative co-stimulatory molecules. Blockade of these negative co-stimulatory pathways, a process known as immune checkpoint modulation, is a promising novel therapy that could improve the treatment of liver diseases that feature T cell exhaustion.
Publish Date	2016-07-22 13:48
Citation	Moreno-Cubero E, Larrubia JR. Specific CD8+ T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis. World J Gastroenterol 2016; 22(28): 6469-6483
URL	http://www.wjgnet.com/1007-9327/full/v22/i28/6469.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i28.6469

Full Article (PDF)	WJG-22-6469.pdf
Full Article (Word)	WJG-22-6469.doc
Manuscript File	25829-Review.docx
Answering Reviewers	25829-Answering reviewers.pdf
Audio Core Tip	25829-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25829-Conflict-of-interest statement.pdf
Copyright License Agreement	25829-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25829-Language certificate.pdf
Peer-review Report	25829-Peer-review(s).pdf
Scientific Misconduct Check	25829-Scientific misconduct check.pdf
Scientific Editor Work List	25829-Scientific editor work list.pdf