Publication Name	World Journal of Gastroenterology
Manuscript ID	25836
Country	Italy

Received	2016-03-24 09:29
Peer-Review Started	2016-03-24 17:31
To Make the First Decision	2016-05-12 14:37
Return for Revision	2016-05-12 15:40
Revised	2016-05-13 00:02
Second Decision	2016-05-14 10:20
Accepted by Journal Editor-in-Chief	2016-05-14 17:09
Accepted by Executive Editor-in-Chief	2016-05-23 16:29
Articles in Press	2016-05-23 16:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-03 14:34
Publish the Manuscript Online	2016-07-06 16:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Topic Highlights
Article Title	HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice
Manuscript Source	Invited Manuscript
All Author List	Federica Grillo, Matteo Fassan, Francesca Sarocchi, Roberto Fiocca and Luca Mastracci
Funding Agency and Grant Number
Corresponding Author	Luca Mastracci, Assistant Professor of Pathology, Department of Surgical and Diagnostic Sciences, Pathology Unit, University of Genoa and IRCCS S. Martino-IST University Hospital, 16132 Genoa, Italy. mastracc@hotmail.com
Key Words	Gastric cancer; HER2; Heterogeneity; Immunohistochemistry; FISH
Core Tip	Accurate assessment of HER2 status is mandatory in gastric/gastroesophageal cancer, for selecting patients who may benefit from targeted therapies with anti-HER2 drugs. The three principle aspects of HER2 evaluation which require consideration are: (1) choice of sample with regards to cancer morphology; (2) choice of scoring criteria; and (3) choice of HER2 evaluation methods. Problematic issues include: (1) pre-analytic variables; (2) recommended methodology for HER2 assessment; (3) HER2 heterogeneity both within the primary tumor and between primary tumor and metastases; (4) reliability of biopsies in HER 2 evaluation; and (5) quantity of sample necessary for adequate assessment.
Publish Date	2016-07-06 16:53
Citation	Grillo F, Fassan M, Sarocchi F, Fiocca R, Mastracci L. HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice. World J Gastroenterol 2016; 22(26): 5879-5887
URL	http://www.wjgnet.com/1007-9327/full/v22/i26/5879.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i26.5879

Full Article (PDF)	WJG-22-5879.pdf
Full Article (Word)	WJG-22-5879.doc
Manuscript File	25836-Review.doc
Answering Reviewers	25836-Answering reviewers.pdf
Audio Core Tip	25836-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	25836-Conflict-of-interest statement.pdf
Copyright License Agreement	25836-Copyright assignment.pdf
Peer-review Report	25836-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25836-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25836-Scientific misconduct check.pdf
Scientific Editor Work List	25836-Scientific editor work list.pdf