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Articles Published Processes
7/6/2016 4:53:00 PM | Browse: 1413 | Download: 2370
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Received |
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2016-03-24 09:29 |
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Peer-Review Started |
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2016-03-24 17:31 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-05-12 15:40 |
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Revised |
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2016-05-13 00:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-05-14 10:20 |
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Second Decision by Editor-in-Chief |
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2016-05-14 17:09 |
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Final Decision by Editorial Office Director |
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2016-05-23 16:29 |
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Articles in Press |
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2016-05-23 16:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-06-03 14:34 |
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Publish the Manuscript Online |
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2016-07-06 16:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Topic Highlights |
| Article Title |
HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Federica Grillo, Matteo Fassan, Francesca Sarocchi, Roberto Fiocca and Luca Mastracci |
| Funding Agency and Grant Number |
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| Corresponding Author |
Luca Mastracci, Assistant Professor of Pathology, Department of Surgical and Diagnostic Sciences, Pathology Unit, University of Genoa and IRCCS S. Martino-IST University Hospital, 16132 Genoa, Italy. mastracc@hotmail.com |
| Key Words |
Gastric cancer; HER2; Heterogeneity; Immunohistochemistry; FISH |
| Core Tip |
Accurate assessment of HER2 status is mandatory in gastric/gastroesophageal cancer, for selecting patients who may benefit from targeted therapies with anti-HER2 drugs. The three principle aspects of HER2 evaluation which require consideration are: (1) choice of sample with regards to cancer morphology; (2) choice of scoring criteria; and (3) choice of HER2 evaluation methods. Problematic issues include: (1) pre-analytic variables; (2) recommended methodology for HER2 assessment; (3) HER2 heterogeneity both within the primary tumor and between primary tumor and metastases; (4) reliability of biopsies in HER 2 evaluation; and (5) quantity of sample necessary for adequate assessment. |
| Publish Date |
2016-07-06 16:53 |
| Citation |
Grillo F, Fassan M, Sarocchi F, Fiocca R, Mastracci L. HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice. World J Gastroenterol 2016; 22(26): 5879-5887 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i26/5879.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i26.5879 |
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