Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	25846
Country	United States

Received	2016-03-24 08:44
Peer-Review Started	2016-03-24 16:33
To Make the First Decision	2016-04-15 08:54
Return for Revision	2016-04-15 11:56
Revised	2016-04-28 02:41
Second Decision	2016-05-16 08:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-02 16:04
Articles in Press	2016-06-02 16:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-18 19:52
Publish the Manuscript Online	2016-08-25 09:10

ISSN	2220-3176 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Challenges in management of recurrent and refractory Clostridium difficile infection
Manuscript Source	Invited Manuscript
All Author List	Anne M Meehan, Raseen Tariq and Sahil Khanna
Funding Agency and Grant Number
Corresponding Author	Sahil Khanna, MBBS, MS, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. khanna.sahil@mayo.edu
Key Words	Clostridium difficile infection; Epidemiology; Outcomes; Treatment; Fecal microbiota transplantation
Core Tip	Recurrent Clostridium difficile infection (RCDI) is common and can be difficult to treat. Clostridia spores transmit disease. They are ubiquitous and hard to eradicate. The composition of the gut microbiome plays an essential yet poorly understood role in main-taining overall health, and in protecting against Clostri-dium difficile (C. difficile) infection. Antibiotic induced dysbiosis of the microbiome is a key contributor to RCDI. Here we review how C. difficile spores and altera-tions in the microbiome contribute to RCDI.
Publish Date	2016-08-25 09:10
Citation	Meehan AM, Tariq R, Khanna S. Challenges in management of recurrent and refractory Clostridium difficile infection. World J Clin Infect Dis 2016; 6(3): 28-36
URL	http://www.wjgnet.com/2220-3176/full/v6/i3/28.htm
DOI	http://dx.doi.org/10.5495/wjcid.v6.i3.28

Full Article (PDF)	WJCID-6-28.pdf
Full Article (Word)	WJCID-6-28.doc
Manuscript File	25846-Review.docx
Answering Reviewers	25846-Answering reviewers.pdf
Audio Core Tip	25846-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	25846-Conflict-of-interest statement.pdf
Copyright License Agreement	25846-Copyright assignment.pdf
Peer-review Report	25846-Peer-review(s).pdf
Scientific Misconduct Check	25846-Scientific misconduct check.pdf
Scientific Editor Work List	25846-Scientific editor work list.pdf