Publication Name	World Journal of Gastroenterology
Manuscript ID	25860
Country	Italy

Received	2016-03-25 14:55
Peer-Review Started	2016-03-25 16:12
To Make the First Decision	2016-05-12 14:34
Return for Revision	2016-05-12 15:48
Revised	2016-05-27 21:31
Second Decision	2016-06-28 09:08
Accepted by Journal Editor-in-Chief	2016-06-28 15:02
Accepted by Executive Editor-in-Chief	2016-07-06 18:25
Articles in Press	2016-07-06 18:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-26 14:47
Publish the Manuscript Online	2016-08-04 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy
Manuscript Source	Invited Manuscript
All Author List	Cristiana Lo Nigro, Vincenzo Ricci, Daniela Vivenza, Cristina Granetto, Teresa Fabozzi, Emanuela Miraglio and Marco C Merlano
Funding Agency and Grant Number
Corresponding Author	Cristiana Lo Nigro, PhD, Laboratory of Cancer Genetics and Translational Oncology, Department of Oncology, S. Croce and Carle Teaching Hospital, via Carle 25, 12100 Cuneo, Italy. lonigro.c@ospedale.cuneo.it
Key Words	Metastatic colorectal cancer; Anti-epidermal growth factor receptor therapy; KRAS; Biomarkers; Antibody-dependent cell-mediated cytotoxicity
Core Tip	This review focuses on progress in the metastatic colorectal cancer (mCRC) personalized treatment and on the role of prognostic and predictive biomarkers available for selecting patients treated with anti-epidermal growth factor receptor (EGFR) therapy. Not only the KRAS mutational status but also BRAF, NRAS, PIK3CA, TP53 and PTEN alterations might be useful in selecting patients who likely will respond to anti-EGFR treatments. In particular, we focused on the following points: (1) predictive biomarkers of response to anti-EGFR therapy; (2) prognostic biomarkers; and (3) new prognostic value of antibody-dependent cell-mediated cytotoxicity activity induced by cetuximab in mCRC.
Publish Date	2016-08-04 17:58
Citation	Lo Nigro C, Ricci V, Vivenza D, Granetto C, Fabozzi T, Miraglio E, Merlano MC. Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy. World J Gastroenterol 2016; 22(30): 6944-6954
URL	http://www.wjgnet.com/1007-9327/full/v22/i30/6944.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i30.6944

Full Article (PDF)	WJG-22-6944.pdf
Full Article (Word)	WJG-22-6944.doc
Manuscript File	25860-Review.doc
Answering Reviewers	25860-Answering reviewers.pdf
Audio Core Tip	25860-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	25860-Conflict-of-interest statement.pdf
Copyright License Agreement	25860-Copyright assignment.pdf
Peer-review Report	25860-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25860-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25860-Scientific misconduct check.pdf
Scientific Editor Work List	25860-Scientific editor work list.pdf