Publication Name	World Journal of Gastroenterology
Manuscript ID	25884
Country	United States

Received	2016-03-25 11:34
Peer-Review Started	2016-03-25 14:52
To Make the First Decision	2016-05-12 14:34
Return for Revision	2016-05-12 16:17
Revised	2016-06-02 05:16
Second Decision	2016-06-06 08:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-15 18:54
Articles in Press	2016-06-15 18:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-14 15:41
Publish the Manuscript Online	2016-07-22 13:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Topic Highlights
Article Title	Immunotherapy in human colorectal cancer: Challenges and prospective
Manuscript Source	Invited Manuscript
All Author List	Xuan Sun, Jian Suo and Jun Yan
Funding Agency and Grant Number
Corresponding Author	Jun Yan, MD, PhD, James Graham Brown Cancer Center, Department of Medicine, Clinical & Translational Research Building, Rm 319, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY 40202, United States. jun.yan@louisville.edu
Key Words	Immunotherapy; Human colorectal cancer; Adoptive cell therapy; Immune checkpoint inhibitor therapy; Immunosuppression
Core Tip	Immunotherapy has recently achieved great clinical objective response in multiple cancer types. However, immunotherapy in human colorectal cancer (CRC) is still in its infancy. Identifying CRC patients who are responding to different forms of immunotherapy is drastically needed. In this review, we will discuss important immunological landscape within the CRC microenvironment and introduce immunoscore system to better describe immunophenotyping in CRC. Knowledge gained from these studies may provide rational design for immunotherapy in human CRC patients.
Publish Date	2016-07-22 13:48
Citation	Sun X, Suo J, Yan J. Immunotherapy in human colorectal cancer: Challenges and prospective. World J Gastroenterol 2016; 22(28): 6362-6372
URL	http://www.wjgnet.com/1007-9327/full/v22/i28/6362.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i28.6362

Full Article (PDF)	WJG-22-6362.pdf
Full Article (Word)	WJG-22-6362.doc
Manuscript File	25884-Review.docx
Answering Reviewers	25884-Answering reviewers.pdf
Audio Core Tip	25884-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25884-Conflict-of-interest statement.pdf
Copyright License Agreement	25884-Copyright assignment.pdf
Peer-review Report	25884-Peer-review(s).pdf
Scientific Misconduct Check	25844-Scientific misconduct check.pdf
Scientific Editor Work List	25884-Scientific editor work list.pdf