Publication Name	World Journal of Hepatology
Manuscript ID	25890
Country	China

Received	2016-03-25 11:22
Peer-Review Started	2016-03-25 15:18
To Make the First Decision	2016-04-18 19:37
Return for Revision	2016-04-19 14:32
Revised	2016-04-29 15:30
Second Decision	2016-05-27 17:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-06-03 16:21
Articles in Press	2016-06-03 16:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-12 10:03
Publish the Manuscript Online	2016-06-14 15:22

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Innate immune targets of hepatitis B virus infection
Manuscript Source	Invited Manuscript
All Author List	Zhi-Qiang Zou, Li Wang, Kai Wang and Ji-Guang Yu
Funding Agency and Grant Number
Corresponding Author	Li Wang, PhD, Infectious Disease Hospital of Yantai, 62 Huanshan Road, Zhifu District, Yantai 264001, Shandong Province, China. liliwang2200@163.com
Key Words	Hepatitis B virus; Infection; Targets; Innate immune response; Signaling pathway
Core Tip	The pathogenesis of hepatitis B virus (HBV) infection is initiated and driven by complicated interplays between the virus and the host immune system. HBV DNA and different HBV proteins have various effects on different arms of innate immune system. The extent of HBV replication as well as the amounts of circulating HBV antigens and different source of HBV proteins have heterogenous effects on innate immune responses and antiviral signaling pathways. Other factors, such as liver inflammation may also have impact on innate immune response. Multiple components of immune responses should be activated in combination with antiviral therapy to disrupt the tolerance to HBV for eliminating HBV infection.
Publish Date	2016-06-14 15:22
Citation	Zou ZQ, Wang L, Wang K, Yu JG. Innate immune targets of hepatitis B virus infection. World J Hepatol 2016; 8(17): 716-725
URL	http://www.wjgnet.com/1948-5182/full/v8/i17/716.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i17.716

Full Article (PDF)	WJH-8-716.pdf
Full Article (Word)	WJH-8-716.doc
Manuscript File	25890-Review.doc
Answering Reviewers	25890-Answering reviewers.pdf
Audio Core Tip	25890-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25890-Conflict of interest statement.pdf
Copyright License Agreement	25890-Copyright assignment.pdf
Peer-review Report	25890-Peer-review(s).pdf
Scientific Misconduct Check	25890-Scientific misconduct check.pdf
Scientific Editor Work List	25890-Scientific editor work list.pdf