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Articles Published Processes
7/15/2016 3:38:00 PM | Browse: 1166 | Download: 1590
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Received |
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2016-03-25 10:54 |
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Peer-Review Started |
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2016-03-25 15:27 |
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To Make the First Decision |
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2016-04-14 10:10 |
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Return for Revision |
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2016-04-14 14:47 |
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Revised |
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2016-05-02 13:21 |
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Second Decision |
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2016-05-11 15:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-05-23 16:34 |
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Articles in Press |
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2016-05-23 16:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-27 12:10 |
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Publish the Manuscript Online |
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2016-07-15 15:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Topic Highlights |
| Article Title |
Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kwang Il Kim, Hye Kyung Chung, Ju Hui Park, Yong Jin Lee and Joo Hyun Kang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Korea Science and Engineering Foundation |
2012M2A2A7013480 |
| Korea Science and Engineering Foundation |
2013M2C2A1074238 |
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| Corresponding Author |
Joo Hyun Kang, PhD, Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812,
South Korea. kang2325@kirams.re.kr
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| Key Words |
Alpha-fetoprotein; Hepatocellular carcinoma; Molecular imaging; Reporter gene; Tumor-specific enhancer/promoter |
| Core Tip |
It is essential to establish an appropriate animal model of hepatocellular carcinoma (HCC) for monitoring the disease progression and evaluating therapeutic interventions with anticancer drugs. Reporter gene-based molecular imaging can elucidate tumor-specific events or processes through acquisition of images of reporter gene expression driven by tumor-specific enhancers/promoters. In this paper, we describe the advantages and disadvantages of various animal models of HCC and present images of in vivo reporter gene expression controlled by alpha-fetoprotein enhancer/promoter in the various HCC animal models.
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| Publish Date |
2016-07-15 15:38 |
| Citation |
Kim KI, Chung HK, Park JH, Lee YJ, Kang JH. Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma. World J Gastroenterol 2016; 22(27): 6127-6134 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i27/6127.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i27.6127 |
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