Publication Name	World Journal of Diabetes
Manuscript ID	25901
Country	Japan

Received	2016-03-26 16:47
Peer-Review Started	2016-03-26 21:11
To Make the First Decision	2016-05-13 16:30
Return for Revision	2016-05-14 19:53
Revised	2016-08-31 10:23
Second Decision	2016-12-26 11:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-01-14 14:50
Articles in Press	2017-01-14 14:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-07 09:28
Publish the Manuscript Online	2017-03-09 16:09

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biology
Manuscript Type	Minireviews
Article Title	Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance
Manuscript Source	Invited Manuscript
All Author List	Tomoki Abe, Katsuya Hirasaka and Takeshi Nikawa
Funding Agency and Grant Number	Funding Agency Grant Number the Japan Society for the Promotion of Science KAKENHI to Tomoki Abe JP15K16208
Corresponding Author	Takeshi Nikawa, MD, PhD, Professor, Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. nikawa@tokushima-u.ac.jp
Key Words	Casitas b-lineage lymphoma-b; Insulin resistance; Macrophage; Obesity; Toll-like receptor 4
Core Tip	Obesity leads to the development of chronic inflammation and insulin resistance (IR). Adipose tissue macrophages (ATMs) play a crucial role in the development of obesity-induced IR. Therefore, ATMs are attractive therapeutic targets for IR. Recently, we demonstrated that the ubiquitin ligase Casitas b-lineage lymphoma-b (Cbl-b) negatively regulates the migration and activation of ATMs. Here, we review key aspects of Cbl-b function in the regulation of ATMs.
Publish Date	2017-03-09 16:09
Citation	Abe T, Hirasaka K, Nikawa T. Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance. World J Diabetes 2017; 8(3): 97-103
URL	http://www.wjgnet.com/1948-9358/full/v8/i3/97.htm
DOI	http://dx.doi.org/10.4239/wjd.v8.i3.97

Full Article (PDF)	WJD-8-97.pdf
Full Article (Word)	WJD-8-97.doc
Manuscript File	25901-Review.docx
Answering Reviewers	25901-Answering reviewers.pdf
Audio Core Tip	25901-Audio core tip.wav
Conflict-of-Interest Disclosure Form	25901-Conflict-of-interest statement.pdf
Copyright License Agreement	25901-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25901-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	25901-Language certificate.pdf
Peer-review Report	25901-Peer-review(s).pdf
Scientific Misconduct Check	25901-Scientific misconduct check.pdf
Scientific Editor Work List	25901-Scientific editor work list.pdf