| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Increased duodenal expression of miR-146a and -155 in pediatric Crohn’s disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Dániel Szűcs, Nóra Judit Béres, Réka Rokonay, Kriszta Boros, Katalin Borka, Zoltán Kiss, András Arató, Attila J Szabó, Ádám Vannay, Erna Sziksz, Csaba Bereczki and Gábor Veres |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hungarian Scientific Research Fund |
OTKA-K105530 |
| Hungarian Scientific Research Fund |
OTKA-K108688 |
| Hungarian Scientific Research Fund |
OTKA--K116928 |
| Hungarian Scientific Research Fund |
OTKA--PD105361 |
| Hungarian Scientific Research Fund |
OTKA-LP008/2016 |
|
| Corresponding Author |
Dániel Szűcs, MD, Department of Pediatrics and Pediatric Health Care Center, University of Szeged, Hungary, Korányi fasor 14-15., H-6725 Szeged, Hungary. szucs.daniel@med.u-szeged.hu |
| Key Words |
Inflammatory bowel disease; Crohn’s disease; Pediatric; MicroRNAs; Transforming growth factor-β |
| Core Tip |
Recent evidence suggests that besides the genetic basis, epigenetic factors including microRNAs (miRs) also act as potent inflammatory modulators during the pathogenesis of inflammatory bowel disease. MiR expression in the upper-gastrointestinal tract of pediatric patients with Crohn’s disease (CD) has not yet been analyzed. Moreover, the relation of transforming growth factor-β, playing a prominent role in the pathomechanism of CD, to miRs in this setting is also unknown. The description of precise miR patterns specific for the different segments of the gastrointestinal tract may contribute to the introduction of novel diagnostic markers and to the identification of potential therapeutic targets. |
| Publish Date |
2016-07-06 16:53 |
| Citation |
Szűcs D, Béres NJ, Rokonay R, Boros K, Borka K, Kiss Z, Arató A, Szabó AJ, Vannay Á, Sziksz E, Bereczki C, Veres G. Increased duodenal expression of miR-146a and -155 in pediatric Crohn’s disease. World J Gastroenterol 2016; 22(26): 6027-6035 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i26/6027.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i26.6027 |
