Publication Name	World Journal of Gastroenterology
Manuscript ID	25923
Country	United States

Received	2016-03-26 16:04
Peer-Review Started	2016-03-26 21:13
To Make the First Decision	2016-05-12 14:33
Return for Revision	2016-05-12 16:24
Revised	2016-06-25 03:25
Second Decision	2016-07-18 08:59
Accepted by Journal Editor-in-Chief	2016-07-19 15:07
Accepted by Executive Editor-in-Chief	2016-08-01 15:24
Articles in Press	2016-08-01 15:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-08-12 10:28
Typeset the Manuscript	2016-09-12 12:13
Publish the Manuscript Online	2016-09-26 08:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Guanylyl cyclase C signaling axis and colon cancer prevention
Manuscript Source	Invited Manuscript
All Author List	Amanda M Pattison, Dante J Merlino, Erik S Blomain and Scott A Waldman
Funding Agency and Grant Number	Funding Agency Grant Number NIH R01CA170533 NIH R01CA206026 NIH P30CA56036 Targeted Diagnostic and Therapeutics, Inc. a Ruth L. Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH CA180500 (To Blomain ES) a Ruth L. Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH F30 DK103492 (To Merlino DJ) a Predoctoral Fellowship in Pharmacology/Toxicology from the PhRMA Foundation
Corresponding Author	Scott A Waldman, MD, PhD, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, United States. scott.waldman@jefferson.edu
Key Words	Colorectal cancer; Guanylin; Uroguanylin; Chemoprevention; Heat-stable enterotoxins; Cyclic guanosine monophosphate; Guanylyl cyclase C
Core Tip	Guanylyl cyclase C (GUCY2C) is a tissue-specific transmembrane receptor found in apical membranes of intestinal enterocytes that drives intestinal homeostatic mechanisms and opposes colorectal tumorigenesis. The receptor’s endogenous hormone ligands, guanylin and uroguanylin, are the most commonly lost gene products in colorectal cancer, making GUCY2C a potential therapeutic target for tumor prevention through hormone replacement therapy.
Publish Date	2016-09-26 08:04
Citation	Pattison AM, Merlino DJ, Blomain ES, Waldman SA. Guanylyl cyclase C signaling axis and colon cancer prevention. World J Gastroenterol 2016; 22(36): 8070-8077
URL	http://www.wjgnet.com/1007-9327/full/v22/i36/8070.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i36.8070

Full Article (PDF)	WJG-22-8070.pdf
Full Article (Word)	WJG-22-8070.doc
Manuscript File	25923-Review.docx
Answering Reviewers	25923-Answering reviewers.pdf
Audio Core Tip	25923-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25923-Conflict-of-interest statement.pdf
Copyright License Agreement	25923-Copyright assignment.pdf
Peer-review Report	25923-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25923-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25923-Scientific misconduct check.pdf
Scientific Editor Work List	25923-Scientific editor work list.pdf