Publication Name	World Journal of Gastroenterology
Manuscript ID	25927
Country	Romania

Received	2016-03-26 15:56
Peer-Review Started	2016-03-26 21:33
To Make the First Decision	2016-05-12 14:33
Return for Revision	2016-05-13 08:44
Revised	2016-05-26 00:00
Second Decision	2016-06-06 08:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-15 18:55
Articles in Press	2016-06-15 18:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-08 15:47
Publish the Manuscript Online	2016-07-15 15:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Hepatitis C virus - associated B cell non-Hodgkin's lymphoma
Manuscript Source	Invited Manuscript
All Author List	Romeo-Gabriel Mihăilă
Funding Agency and Grant Number
Corresponding Author	Romeo-Gabriel Mihăilă, MD, PhD, Professor, Chief, Hematology Department, Emergency County Clinical Hospital Sibiu, Bulevardul Corneliu Coposu 2-4, 550245 Sibiu, Romania. romeomihaila@yahoo.com
Key Words	Chemotherapy; Cryoglobulinemia; Direct acting antiviral drugs; Hepatitis C virus; Hepatocytolysis; Interferon; Liver transplantation; Liver dysfunction; Non-Hodgkin’s lymphoma; Rituximab
Core Tip	There are epidemiological observations on the association between hepatitis C virus (HCV) infection and non-Hodgkin's lymphoma. Various microenvironmental signals, such as cytokines, viral antigenic external stimulation of lymphocyte receptors by HCV antigens, and intercellular interactions contribute to B cell proliferation. HCV lymphotropism and chronic antigenic stimulation are involved in B-lymphocyte expansion, as mixted cryoglobulinemia or monoclonal gammopathy of undetermined significance, which can progress to B cell non-Hodgkin's lymphoma (BCNHL). HCV infected patients with indolent BCNHL who receive antiviral therapy can be potentially cured. Viral clearance was related to lymphoma response, fact that highlights the probable involvement of HCV in lymphomagenesis.
Publish Date	2016-07-15 15:38
Citation	Mihăilă R. Hepatitis C virus - associated B cell non-Hodgkin's lymphoma. World J Gastroenterol 2016; 22(27): 6214-6223
URL	http://www.wjgnet.com/1007-9327/full/v22/i27/6214.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i27.6214

Full Article (PDF)	WJG-22-6214.pdf
Full Article (Word)	WJG-22-6214.doc
Manuscript File	25927-Review.docx
Answering Reviewers	25927-Answering reviewers.pdf
Audio Core Tip	25927-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25927-Conflict-of-interest statement.pdf
Copyright License Agreement	25927-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25927-Language certificate.pdf
Peer-review Report	25927-Peer-review(s).pdf
Scientific Misconduct Check	25927-Scientific misconduct check.pdf
Scientific Editor Work List	25927-Scientific editor work list.pdf