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Articles Published Processes
8/17/2016 6:59:00 PM | Browse: 923 | Download: 1289
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Received |
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2016-03-26 15:38 |
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Peer-Review Started |
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2016-03-27 19:40 |
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To Make the First Decision |
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2016-05-13 16:31 |
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Return for Revision |
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2016-05-14 20:42 |
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Revised |
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2016-05-20 11:16 |
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Second Decision |
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2016-06-12 10:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-06-29 09:14 |
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Articles in Press |
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2016-06-29 09:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-08-12 16:14 |
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Publish the Manuscript Online |
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2016-08-17 18:59 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jessica Amber Jennings, Karen E Beenken, Robert A Skinner, Daniel G Meeker, Mark S Smeltzer, Warren O Haggard and Karen S Troxel |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Biomet, LLC |
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| Corresponding Author |
Jessica Amber Jennings, PhD, Assistant Professor, Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building, Memphis, TN 38152, United States. jjnnings@memphis.edu
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| Key Words |
Biofilm; Implant; Drug delivery coating; Antibiotic; Orthopaedic infection |
| Core Tip |
We report infection preventative results of a novel antibiotic-loaded coating in a severe contami-nated model of orthopaedic infection. Phosphatidylcho-line coatings loaded with 25% vancomycin, which can be applied to implants immediately prior to implantation, significantly reduced staphylococcal adherence to intramedullary titanium wires in rabbits. Reduction in bacterial load on implants and in tissue for antibiotic-loaded coatings accompanied reduction in swelling and pus formation. Mild inflammatory responses were noted with coated implants compared to uncoated infected controls. This preliminary short term study demonstrates the clinical potential of these broadly applicable coatings and the need for further characterization and development.
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| Publish Date |
2016-08-17 18:59 |
| Citation |
Jennings JA, Beenken KE, Skinner RA, Meeker DG, Smeltzer MS, Haggard WO, Troxel KS. Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection. World J Orthop 2016; 7(8): 467-474 |
| URL |
http://www.wjgnet.com/2218-5836/full/v7/i8/467.htm |
| DOI |
http://dx.doi.org/10.5312/wjo.v7.i8.467 |
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