Publication Name	World Journal of Gastroenterology
Manuscript ID	25957
Country	China

Received	2016-03-27 09:30
Peer-Review Started	2016-03-27 13:51
To Make the First Decision	2016-05-12 14:31
Return for Revision	2016-05-13 08:55
Revised	2016-05-16 17:26
Second Decision	2016-05-23 08:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-06-02 15:34
Articles in Press	2016-06-02 15:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-07-01 02:44
Typeset the Manuscript	2016-08-12 15:42
Publish the Manuscript Online	2016-08-24 10:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Protein and gene expression characteristics of heterogeneous nuclear ribonucleoprotein H1 in esophageal squamous cell carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Lin Sun, Fei Liu, Fang Liu and Xiao-Hang Zhao
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 81572840 Natural Science Foundation of China 81572365 State Key Project for Basic Research 2014CBA02002 National High-tech R & D Program 2012AA020206
Corresponding Author	Xiao-Hang Zhao, MD, PhD, Professor, State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Panjiayuan Nanli 17, Chaoyang District, Beijing 100021, China. zhaoxh@cicams.ac.cn
Key Words	Heterogeneous nuclear ribonucleoprotein H1; Esophageal squamous cell carcinoma; Alternative transcript variants; Biomarker
Core Tip	Heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1) is an evolutionarily conserved splicing factor. It is involved in alternative splicing, polya?denylation, mRNA export, and translation. This study investigated the expression, localization, and clinical significance of HNRNPH1 in esophageal squamous cell carcinoma (ESCC). We found that this gene posse?sses two alternative transcript variants; one was constitutively expressed, while the other was regulated and dramatically increased in ESCC. HNRNPH1 protein was overexpressed in ESCC tissues. Strong HNRNPH1 levels were associated with poorer tumor differentiation and alternative splicing of apoptosis-related genes. These findings suggest that HNRNPH1 is a potential diagnostic biomarker and therapeutic target for ESCC.
Publish Date	2016-08-24 10:09
Citation	Sun YL, Liu F, Liu F, Zhao XH. Protein and gene expression characteristics of heterogeneous nuclear ribonucleoprotein H1 in esophageal squamous cell carcinoma. World J Gastroenterol 2016; 22(32): 7322-7331
URL	http://www.wjgnet.com/1007-9327/full/v22/i32/7322.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i32.7322

Full Article (PDF)	WJG-22-7322.pdf
Full Article (Word)	WJG-22-7322.doc
Manuscript File	25957-Review.docx
Answering Reviewers	25957-Answering reviewers.pdf
Audio Core Tip	25957-Audio core tip.mp3
Biostatistics Review Certificate	25957-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25957-Conflict-of-interest statement.pdf
Copyright License Agreement	25957-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25957-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	25957-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	25957-Institutional review board statement.pdf
Peer-review Report	25957-Peer-review(s).pdf
Scientific Misconduct Check	25957-Scientific misconduct check.pdf
Scientific Editor Work List	25957-Scientific editor work list.pdf